Comprehensive review of biosynthesis, plant function, metabolism and new therapeutic bioactivities of flavonoids.
Level 5 - mechanism / opinion, no new human data
Narrative literature review synthesizing mechanistic and translational concepts without systematic review methodology.
PubMed 42633482 · doi:10.5599/admet.3404
What was done
The authors performed a narrative literature review searching Google Scholar, Scopus, and ScienceDirect to assess flavonoid biosynthesis, biological function in plants, human metabolism, and therapeutic bioactivities in cardiovascular disease, diabetes, and cancer.
What was found
The abstract provides no numerical data, effect sizes, or study counts. It qualitatively reports that flavonoids possess antioxidant, anti-inflammatory, and neuroprotective properties, but clinical application is constrained by poor bioavailability, inadequate human tissue concentrations, and absence of standardized dosing. Future priorities identified include creating structural analogs to improve absorption, evaluating drug synergy, and studying microbiome interactions.
Why it matters
This paper frames the key translational gaps that prevent laboratory-tested plant flavonoids from becoming reliable, standardized clinical therapies.
Limits
The abstract provides no primary data, sample sizes, or quantitative results. Search methods were narrative rather than systematic, with no reported screening protocol, quality grading, or risk of bias evaluation.
Cited by
- supports Animals do not produce polyphenols.