Denenberg · Sleep 1981 · observational cohort study · n=22

Evidence for a functional role for active (REM) sleep in infancy.

Cited 43 times in the scientific literature.

Level 4 - case-series / case-control

Small observational cross-sectional/cohort correlational study without a comparison group.

PubMed 7256079 · record verified 2026-08-26

What was done

Analyzed sleep-wake data from 22 normal infants to test deductions derived from the hypothesis that active (REM) sleep serves an endogenous functional role in stimulating the central nervous system to facilitate growth and maturation.

What was found

The amount of time spent in the behavioral state of Quiet Alert correlated -0.82 with the state of Active Sleep. The correlation was reported to be independent of maturational changes in the infants.

Why it matters

Provides early observational support for the hypothesis that active sleep functions as a source of endogenous stimulation for infant central nervous system development.

Limits

Small sample size (n = 22). Purely observational and correlational design without experimental manipulation. The abstract does not provide exact age distributions, recording duration, or confidence intervals.

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