Adolphs · Nature 1994 · single-case neuropsychological study · n=1

Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.

Cited 2362 times in the scientific literature.

Level 4 - case-series / case-control

Single human case study of a patient with selective bilateral amygdala lesions

PubMed 7990957 · doi:10.1038/372669a0 · record verified 2026-08-26

What was done

Researchers tested face processing and emotion recognition abilities in a single patient with rare, selective bilateral lesions to the amygdala, evaluating recognition of facial identity, specific emotions (such as fear), and multiple concurrent emotions within single facial expressions.

What was found

The abstract provides no numerical data or test scores. It reports that bilateral amygdala damage impaired the recognition of fear in facial expressions and the ability to detect multiple emotions in a single expression, whereas the ability to recognize personal identity from faces was preserved.

Why it matters

This study provides evidence that the human amygdala is not required for general facial identity recognition, but is specifically necessary for interpreting emotional facial expressions, particularly fear.

Limits

The study is restricted to a single patient (n = 1), making broad generalization difficult. The abstract does not report quantitative performance metrics, lesion etiology, or formal comparison to matched healthy controls.

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