Lewy body disease and dementia with Lewy bodies
Level 5 - mechanism / opinion, no new human data
Narrative review and historical expert perspective with no new empirical dataset or systematic methodology
OpenAlex W2046840148 · doi:10.2183/pjab.90.301
What was done
This is a narrative and historical review outlining the author's work on autopsied cases since 1976 that led to proposing the terms and diagnostic frameworks for diffuse Lewy body disease (DLBD) and Lewy body disease (LBD).
What was found
The abstract contains no numerical data or statistical metrics. It describes the historical classification of LBD based on Lewy body distribution into brainstem, transitional, diffuse, and cerebral types, and notes that LBD functions as an umbrella term covering Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies (the second most common dementia after Alzheimer's disease).
Why it matters
The paper documents the conceptual and pathological evolution of diagnostic criteria and disease staging for Lewy body spectrum disorders from the pioneering group that originally introduced the terminology.
Limits
The abstract is purely descriptive and historical, lacking methodological details, study cohort sizes, statistical testing, or quantitative comparative findings.
Cited by
- supports Dementia with Lewy bodies was not described in the medical literature until 1976.