Chris J. McNeil · Frontiers in Human Neuroscience 2013 · narrative review · n=?

Testing the excitability of human motoneurons

Cited 220 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review of neurophysiological methodologies with no primary data or systematic search syntax.

OpenAlex W2117620243 · doi:10.3389/fnhum.2013.00152 · record verified 2026-08-26

What was done

This narrative methodological review evaluated the primary neurophysiological techniques used to assess the excitability of human motoneuron pools via evoked compound muscle action potentials. The specific modalities reviewed included the Hoffmann reflex (H-reflex), F-wave, tendon jerk reflex, volitional wave (V-wave), cervicomedullary motor evoked potentials (CMEP), and motor evoked potentials (MEP).

What was found

The abstract provides no quantitative data or numerical outcomes. It qualitatively notes that while these methods allow researchers to assess whether neuroplastic adaptations following exercise, injury, disuse, or disease occur at cortical versus spinal levels, each technique presents distinct operational advantages and methodological limitations.

Why it matters

Accurate assessment of motoneuron pool excitability is essential for isolating the physiological mechanisms and anatomical sites of central nervous system adaptations.

Limits

The abstract reports no primary experimental data, sample sizes, quantitative comparisons, or systematic review protocols. Specific limitations and error profiles inherent to each evoked-potential technique are mentioned conceptually but not detailed numerically in the abstract.

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