Aubrey D.N.J. de Grey · Journal of Medical Ethics 2005 · bioethical essay / opinion · n=?

Life extension, human rights, and the rational refinement of repugnance

Cited 59 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Philosophical essay and expert opinion with no empirical human data (design analogy)

OpenAlex W2127683975 · doi:10.1136/jme.2005.011957 · record verified 2026-08-29

What was done

This is a conceptual bioethical essay examining societal ambivalence toward radical and indefinite human life extension. The author analyzed ethical, psychological, and human rights arguments regarding whether developing biomedical interventions to cure biological aging is morally desirable and defensible.

What was found

The abstract reports no empirical data or quantitative findings. The author presents theoretical arguments asserting that objections to curing aging function primarily as psychological coping mechanisms for an immutable reality, that these objections conflict with more fundamental human values supporting health and life preservation, and that hesitation to pursue anti-aging biomedical research delays life-saving discoveries.

Why it matters

The paper articulates a foundational pro-longevity bioethical position, framing the eradication of biological aging as a direct extension of standard healthcare and human rights.

Limits

This work is purely normative and conceptual, containing no clinical, experimental, or observational human data. It represents the reasoning and perspective of a single author rather than an empirical test or systematic evidence synthesis.

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