James S. Yeh · JAMA Internal Medicine 2016 · cross-sectional study · n=2444

Association of Industry Payments to Physicians With the Prescribing of Brand-name Statins in Massachusetts

Cited 216 times in the scientific literature.

Level 4 - case-series / case-control

Cross-sectional observational linkage study

OpenAlex W2346692005 · doi:10.1001/jamainternmed.2016.1709 · record verified 2026-08-28

What was done

This cross-sectional study linked 2011 Medicare Part D prescription claims data with the Massachusetts physician payment database for all licensed Massachusetts physicians prescribing statins under Medicare Part D. Linear regression was used to analyze the association between total industry payments and specific payment types received by physicians and their rate of prescribing brand-name versus generic statins.

What was found

Among 2,444 physicians with 1,559,003 statin claims (356,807 [22.8%] brand-name), 899 (36.8%) received industry payments, most commonly for company-sponsored meals (639 [71.1%]). Physicians receiving no payments had a median brand-name prescribing rate of 17.8% (95% CI, 17.2%-18.4%). For every $1,000 in total payments received, the brand-name prescribing rate increased by 0.1% (95% CI, 0.06%-0.13%; P < .001). Payments for educational training were associated with a 4.8% increase in brand-name prescribing (P = .004); other payment types showed no significant association.

Why it matters

Industry payments to physicians, especially for educational training, are associated with increased prescribing of more expensive brand-name statins over generics, contributing to higher drug costs.

Limits

The cross-sectional design cannot establish causality or determine whether payments influenced prescribing or targeted physicians already prescribing brand-name statins. Data are restricted to Medicare Part D beneficiaries, one state (Massachusetts), a single drug class, and one calendar year (2011).

Cited by