Rotenone: from modelling to implication in Parkinson’s disease
Level 5 - mechanism / opinion, no new human data
Narrative review focusing on environmental exposure and preclinical animal models
OpenAlex W2993039061 · doi:10.5114/fn.2019.89857
What was done
This narrative review synthesized literature on the environmental hazards of rotenone, its application as an experimental model reproducing Parkinson's disease features in rodents, and its implicated role in the etiopathogenesis of the disease.
What was found
The abstract reports no numerical data. It notes that rotenone reproduces behavioral, biochemical, and pathological features of Parkinson's disease in rat models and serves as a tool to investigate pathogenic mechanisms and test potential therapies.
Why it matters
The review summarizes the role of rotenone both as an environmental risk factor for neurodegeneration and as a foundational chemical model used to evaluate novel Parkinson's disease therapeutics.
Limits
As an unstructured narrative review, it lacks a systematic search protocol and formal study quality appraisal. The findings are based on preclinical animal and mechanistic models without human clinical data.
Cited by
- context Rotenone is banned as a pesticide in the United States and the European Union.