Jonathan C. K. Wells · Frontiers in Endocrinology 2020 · Theoretical / conceptual review · n=?

Life History Transitions at the Origins of Agriculture: A Model for Understanding How Niche Construction Impacts Human Growth, Demography and Health

Cited 128 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Theoretical framework and narrative review with no primary empirical data (design analogy).

OpenAlex W3027966289 · doi:10.3389/fendo.2020.00325 · record verified 2026-08-27

What was done

This paper presents a theoretical framework applying evolutionary life history theory to understand the shift from foraging to agriculture over the past 12,000 years. The authors synthesized evolutionary principles of finite energy allocation across four competing biological functions—maintenance, growth, reproduction, and defense—to evaluate how dietary changes, sedentarism, and altered infectious burdens shaped human demography and health.

What was found

The abstract reports no numerical results or empirical statistical analyses. Conceptually, the model proposes that the agricultural niche increased total energy availability but introduced new infectious exposures and altered diet composition. Natural selection favored allocating energy toward reproduction (driving population growth) and immune defense, resulting in reduced somatic allocation toward growth (reduced adult stature) and maintenance (poorer health and survival markers).

Why it matters

It provides an overarching evolutionary explanation for the long-standing paradox of expanding human populations occurring alongside declining individual health markers during the agricultural transition, offering a lens to study contemporary nutrition transitions.

Limits

The abstract describes a conceptual model and narrative review rather than an empirical study or systematic review; no primary human data, sample sizes, or quantitative effect sizes are provided. The hypotheses regarding historical energetic trade-offs cannot be directly verified through observational or experimental measurement in past populations.

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