The use of hydroxyapatite toothpaste to prevent dental caries
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analytic pooling
OpenAlex W3214961941 · doi:10.1007/s10266-021-00675-4
What was done
This narrative review summarizes recent in vitro, in situ, and in vivo research evaluating the remineralization potential of micro- and nanocrystalline hydroxyapatite toothpaste as a fluoride-free anti-caries agent, along with other dental applications.
What was found
The abstract reports no numerical findings, effect sizes, or statistical metrics. It states qualitatively that hydroxyapatite particles deposit on and restore demineralized enamel surfaces.
Why it matters
It highlights the mechanistic and experimental basis for hydroxyapatite toothpaste as an alternative fluoride-free option for dental caries prevention.
Limits
As a narrative review, it does not use systematic search or meta-analytic methodology. The abstract provides no quantitative data, sample sizes, or direct comparative evidence against standard fluoride dentifrices.
Cited by
- supports Hydroxyapatite dental remineralization technology was developed by NASA and has been used in commercial oral care products in Japan for 40 years.