A century of exercise physiology: key concepts in regulation of glycogen metabolism in skeletal muscle
Level 5 - mechanism / opinion, no new human data
Narrative review of historical and mechanistic concepts with no new empirical human data
OpenAlex W4220824452 · doi:10.1007/s00421-022-04935-1
What was done
Narrative review examining the evolution of key concepts in skeletal muscle glycogen metabolism over the past century. The abstract addresses historical frameworks and emerging revisions regarding glycogenin-dependent priming, glycogen phosphorylase regulation during contraction, and glycogen resynthesis mechanisms during exercise recovery.
What was found
The abstract reports no quantitative data or specific numerical results. It notes that glycogen accumulation occurs even without functional glycogenin, challenging the requirement of glycogenin as an obligate primer. It also indicates that traditional models of phosphorylase b-to-a conversion during intense muscle contraction and post-exercise glycogenesis regulation require modification.
Why it matters
Synthesizes a century of exercise physiology concepts and clarifies where foundational assumptions about glycogen metabolism in skeletal muscle require updated mechanistic models.
Limits
Narrative overview with no original empirical data, quantitative analyses, or systematic search methodology presented in the abstract. Clinical and practical implications are not quantified.
Cited by
- context In the 1960s, Jonas Bergström developed the percutaneous muscle biopsy technique and showed that glucose is stored in muscle as glycogen.