Inaugural year of regulated psilocybin services in Oregon: safety, motivations, and utilization
Level 4 - case-series / case-control
Descriptive analysis of statewide aggregate administrative data
OpenAlex W7161045271 · doi:10.3389/fpsyt.2026.1777387
What was done
Descriptive analysis of statewide aggregate data from the Oregon Psilocybin Services (OPS) Public Dashboard covering the inaugural operational year (January 1 to December 31, 2025). The study evaluated total service volume, client demographics, out-of-state participation, and acute adverse events.
What was found
A total of 5,935 clients engaged in 5,375 sessions in 2025, with session counts peaking in Q2 (n = 1,758) and stabilizing in Q4 (n = 1,358). Non-Oregon residents comprised 32.6% of participants. The cohort was predominantly aged 35–49 (~40%), female (57.4%), and included notable LGBTQ+ participation (27.2%). Participants were overwhelmingly White (84.1%–91.5% quarterly), with low participation from Hispanic/Latino (7.1%) and African American (2.1%) individuals. Acute adverse events were rare, with annual rates of 2.42 behavioral events and 2.79 medical events per 1,000 sessions.
Why it matters
This paper provides the first population-level safety and utilization metrics for a state-regulated psilocybin framework in the United States, highlighting practical safety feasibility alongside substantial demographic access disparities.
Limits
The study is limited to aggregated administrative dashboard data without individual-level medical or psychological assessments, precluding efficacy evaluations, baseline diagnostic verification, or longitudinal follow-up. Adverse event rates rely on self- or facilitator-reported registry data, which may be subject to underreporting.
Cited by
- partial Close to 10,000 or more people have participated in regulated adult-assisted magic mushroom experiences in states like Oregon.