FoundMyFitness · 2026-06-10 · Rhonda Patrick (host), Steve Horvath
The 7 Habits of People Who Age Slower | Dr. Steve Horvath
73 claims checked against research: 3 contradicted 7 overstated 6 needing context 52 supported 5 unverified
5 No source found (not proven false)
Applying the Horvath pan-tissue clock to sperm yields a constant uninformative value of approximately 37 across individuals.
"So for example, what is known as the Horvath pan-tissue clock, you apply to sperm you get one number: 37 or so, [laughter] but everybody has the same number in essence, you know, uninformative." (said at 0:26:50)
No published record matching the claim that applying the Horvath pan-tissue clock to sperm yields a constant value of approximately 37 across individuals was located; this does not prove the claim false.
The FDA has not approved or qualified any aging biomarker as an official surrogate endpoint for clinical trials.
"the biomarker field has not yet developed any biomarker that is credible to the FDA when it comes to this ambition of being an official surrogate endpoint of a clinical trial." (said at 0:38:03)
No published record matching the claim that the FDA has not approved or qualified any aging biomarker as an official surrogate endpoint for clinical trials was located; this does not prove the claim false.
Anti-TNF-alpha therapy reverses epigenetic age in patients with autoimmune disease.
"So the other intervention that has very strong evidence is anti-TNF-alpha therapy, really anti-inflammatory drugs for people who have an autoimmune disease." (said at 0:41:06)
No published record matching the claim that anti-TNF-alpha therapy reverses epigenetic age in patients with autoimmune disease was located; this does not prove the claim false. Published studies on DNA methylation and epigenetic clocks in autoimmune conditions (such as psoriasis and rheumatoid arthritis) have examined cross-sectional differences in epigenetic age acceleration or predicted treatment response based on baseline DNA methylation patterns (e.g., PMID: 33015854, PMID: 37698382, PMID: 39797936), but direct longitudinal published evidence demonstrating reversal of epigenetic age following anti-TNF-alpha therapy in human patients was not found in PubMed or Europe PMC.
In animal transplantation experiments by Vadim Gladyshev's group, replacing blood or stem cells with those from a young mouse did not rejuvenate other organs, and the transplanted stem cells aged in the old recipient.
"They didn't rejuvenate other organs. If anything, there was um a disappointing result that um after x number of months, actually the stem cells had aged. So the body has the memory of the old mouse, and that then aged the the the blood." (said at 1:02:20)
No published record matching the claim that Vadim Gladyshev's group conducted stem cell or blood transplantation experiments in which young stem cells aged in the old recipient body without rejuvenating other organs was located; this does not prove the claim false.
In a multivitamin trial analysis (COSMOS subset), GrimAge and PhenoAge detected a statistically significant deceleration of epigenetic aging of 2.7 to 5 months over 2 years, whereas DunedinPACE did not reach statistical significance.
"here GrimAge found an effect, PhenoAge found an effect based on multivitamin use, but DunedinPACE failed. It was not significant, you know... When it comes to looking at these epigenetic aging clocks, the PhenoAge and GrimAge clocks were the ones that stood out to me. As you mentioned, there was a battery of clocks that were that were looked at, but it seemed as though they were slowing, or at least—I'm not exactly sure all the calculations that go into this—but 2.7 months to 5 months, right? Like they were basically they're they're slowing the aging by roughly that amount." (said at 1:12:43)
No published record matching the specific epigenetic clock findings (GrimAge, PhenoAge, and DunedinPACE deceleration effects) in the multivitamin trial analysis was retrieved in full; this does not prove the claim false.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.