FoundMyFitness · 2022-04-12 · Rhonda Patrick (host), Morgan Levine
Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration — can we change the pace?
52 research-tied claims examined: 1 contradicted 1 overstated 1 context 45 supported 4 unverified
4 No source found (not proven false)
Epigenetic clock methylation changes occur most rapidly during development, become steady around age 20, and slow down after age 80.
"The epigenetic clocks show a totally different pattern: it's still not linear, but actually most of the changes happen during development. So you have this huge increase in epigenetic age between—we can even measure it in fetal samples—and then it kind of starts becoming more linear and steady around age 20. And then interestingly, it actually slows down again in very late life, so after let's say age 80." (said at 0:24:05)
No published record matching the claim that epigenetic clock methylation changes occur most rapidly during development, stabilize around age 20, and slow down after age 80 was located; this does not prove the claim false.
Developing a chronic disease is associated with a shortened time interval to developing subsequent chronic diseases.
"And we do know, not looking at epigenetics, that once you get a disease, it's actually shorter time to each subsequent disease." (said at 0:25:30)
No published record matching the claim that developing a chronic disease is associated with a shortened time interval to each subsequent disease was located; this does not prove the claim false.
A six-month trial of 5 grams per day of EPA/DHA fish oil in women genetically predisposed to breast cancer showed hypomethylation in inflammatory pathways such as TNF-alpha in PBMCs.
"The study was women that were genetically predisposed to breast cancer, they were given five grams a day of fish oil, so it was EPA/DHA omega-3, the marine omega-3 fatty acids, and this was like six months treatment. And they had done some sort of methylation profiling—not epigenetic clock, but profiling of their PBMCs, their peripheral blood mononuclear cells, and there was like hypomethylation in I think it was like TNF-alpha or some one of the major controllers of inflammation where it was decreasing inflammation." (said at 1:01:57)
No published record matching a six-month trial of 5 grams per day of EPA/DHA fish oil measuring PBMC DNA methylation in women genetically predisposed to breast cancer was located; this does not prove the claim false.
Exercise has been shown to reverse diabetes better than metformin.
"Or they've even shown you can reverse diabetes through exercise or any of these things better than metformin." (said at 1:14:08)
No published record matching the claim that exercise reverses diabetes better than metformin was located; this does not prove the claim false. While landmark clinical trials such as the Diabetes Prevention Program demonstrated that intensive lifestyle interventions (combining diet and physical activity) were more effective than metformin at preventing or delaying the onset of type 2 diabetes in individuals with prediabetes, these findings pertain to diabetes prevention rather than the reversal or remission of established type 2 diabetes.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.