DavidPerlmutterMD · 2025-03-24 · David Perlmutter (host), Dale Bredesen
How to Make Your Brain Ageless: Prevent Cognitive Decline & Supercharge Your Mind | Dale Bredesen
43 research-tied claims examined: 1 contradicted 5 overstated 3 context 28 supported 6 unverified
6 No source found (not proven false)
An interim analysis of an ongoing randomized controlled trial comparing a precision medicine protocol to standard neurological care for cognitive decline showed a statistically significant improvement in treated patients and no statistically significant change in the control group.
"we've done essentially a halfway analysis for the entire trial, and there's a statistically significant improvement in the patients who are treated. And the control group, which is getting standard of care neurological treatment for cognitive decline, um, there is no statistically significant difference." (said at 0:02:54)
No published record matching an interim analysis of an ongoing randomized controlled trial comparing this precision medicine protocol to standard neurological care was located; this does not prove the claim false. Published peer-reviewed research by this investigator includes an uncontrolled proof-of-concept pilot study of 25 patients (published in 2022) and case series reporting cognitive improvements, which noted that a larger randomized controlled trial was warranted. However, formal peer-reviewed results or interim findings from a subsequent randomized controlled trial with a standard-of-care control arm have not been published.
A study published around 2023 examining brains of normal individuals, Alzheimer's patients, and Parkinson's patients found that the majority of organisms in the normal brain microbiome were oral microbiota.
"And here is a really interesting study I'm sure you're aware of, came out 2 years ago. And what they showed was just taking normal brains, Alzheimer brains, and Parkinson's brains and looking at various regions of the brain and then doing sequencing and asking what are the things that are in a quote "normal" brain microbiome... the majority of the organisms that were found in the normal brain microbiome were, guess what? Oral microbiota." (said at 0:13:46)
No published record matching the claim that a study comparing postmortem brain tissue from normal individuals, Alzheimer's patients, and Parkinson's patients identified a normal brain microbiome dominated by oral microbiota was located; this does not prove the claim false.
A published study comparing stool analysis in 20 multiple sclerosis patients versus controls found distinct species-level microbiome differences.
"one of the first published studies that we did was on a series of 20 patients with MS versus control of their stool analysis, and we found some very interesting uniqueness. And this is these are data, we're just looking at the species level." (said at 0:30:45)
No published record matching a study of stool microbiome analysis in 20 multiple sclerosis patients versus controls authored by the speaker was located; this does not prove the claim false.
Two late-70s ApoE4 homozygous patients with early Alzheimer's symptoms who followed the ReCODE protocol showed normalized or borderline p-tau biomarker levels.
"we've had two people recently that uh both ApoE4/4, both in their late 70s, both had symptoms about 5 years ago, were starting to have Alzheimer's disease. They both went on the protocol. They both did very well. They both just checked their p-taus, and one of them's completely normal, the other one's borderline to indeterminate." (said at 0:33:24)
No published record matching the specific claim of two late-70s ApoE4/4 homozygous patients with Alzheimer's symptoms demonstrating normalized or borderline p-tau biomarker levels after following the ReCODE protocol was located; this does not prove the claim false. While publications evaluating the ReCODE protocol and multi-factorial precision medicine interventions for cognitive decline report cognitive scores (such as MoCA) and metabolic markers in patient cohorts and case series, specific clinical data documenting p-tau normalization in this described ApoE4 homozygous patient pair have not been indexed in published peer-reviewed records.
A published study showed an association between metformin use and increased neurodegeneration.
"There was a study a number of years ago that showed increased neurodegeneration in people who had taken metformin." (said at 0:54:45)
No published record matching the claim that metformin use is associated with increased neurodegeneration was located; this does not prove the claim false.
Differences in infant gut microbiome composition associated with the method of birth largely normalize by two to three years of age.
"these influences on an infant microbiome based upon method of birth are pretty profound and lifelong. For the most part they self-correct at two or three years" (said at 1:04:44)
No published record matching the claim that differences in infant gut microbiome composition associated with the method of birth largely normalize by two to three years of age was located; this does not prove the claim false.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.