37 claims checked against research: 2 overstated 4 needing context 29 supported 2 unverified
"we know that fasting increases NAD levels and the NAD and NADH ratio." (said at 0:36:00)
No published record matching the claim that fasting increases NAD levels and the NAD and NADH ratio was located; this does not prove the claim false.
"So we have shown in the skin, for example, that with age, um senescent cells do accumulate, but if you clear those cells, you don't get much benefit and that's because by old age, you've depleted the stem cells." (said at 0:38:46)
No published record matching the claim that clearing senescent cells from aged mouse skin provides little regenerative benefit due to exhaustion or depletion of the stem cell pool was located; this does not prove the claim false. While published mouse models from the Campisi laboratory demonstrate that senescent fibroblasts and endothelial cells transiently promote cutaneous wound healing via PDGF-AA secretion (and that their clearance can delay acute wound repair), the specific finding that senolytic clearance fails to rejuvenate aged skin because of stem cell pool depletion has not been documented in the indexed literature.