DavidPerlmutterMD · 2025-02-10 · David Perlmutter (host), Austin Perlmutter
Is Lifting Weights the Best Dementia Prevention? Muscle’s Impact on Brain Health | Dr. Perlmutter
44 research-tied claims examined: 1 contradicted 2 overstated 4 context 32 supported 5 unverified
5 No source found (not proven false)
Skeletal muscle can constitute up to 40% of body weight and contains up to 75% of total body protein.
"skeletal muscle can be up to 40% of a person's body weight, which really makes it the largest tissue, and it contains up to 75% of the protein in your body." (said at 0:06:12)
No published record matching the claim that skeletal muscle constitutes up to 40% of body weight and contains up to 75% of total body protein was located; this does not prove the claim false.
The majority of BDNF required for neuroplasticity is synthesized locally within the brain rather than peripherally.
"it seems like the majority of the BDNF that's important for neuroplasticity is actually produced locally in the brain, which throws off this whole idea that it's peripheral levels that matter." (said at 0:30:25)
No published record matching the claim that the majority of BDNF required for neuroplasticity is synthesized locally within the brain rather than peripherally was located; this does not prove the claim false.
SSRIs and SNRIs fail to work in about one-third of people with depression even after multiple medications are tried.
"What we've seen is not only does this drug not work in about a third of people, even after multiple kind of agents are used in the SSRI/SNRI family" (said at 0:37:01)
No published record matching the claim that SSRIs and SNRIs fail to work in about one-third of people with depression even after multiple medications are tried was located; this does not prove the claim false.
Consuming large amounts of branched-chain amino acids over extended periods can contribute to metabolic dysfunction.
"some of these branched-chain amino acids can actually lead to metabolic dysfunction when consumed in large amounts over long periods of time." (said at 0:50:44)
No published record matching the claim that consuming large amounts of branched-chain amino acids over extended periods contributes to metabolic dysfunction was located; this does not prove the claim false.
The majority of human skeletal muscle mass and the largest skeletal muscles in the body are located in the legs.
"the majority of your skeletal muscle mass: the biggest skeletal muscles in your body are in your legs." (said at 1:05:18)
No published record matching the claim regarding the exact proportion of total body skeletal muscle mass located in the lower limbs versus other anatomical regions was located; this does not prove the claim false.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.