FoundMyFitness · 2023-12-27 · Rhonda Patrick (host), Peter Attia
Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
135 research-tied claims examined: 13 contradicted 8 overstated 16 context 83 supported 15 unverified
15 No source found (not proven false)
In the United States, someone dies from cardiovascular disease every 33 seconds.
"there's a statistic that I've read from the National Health Statistics website, which is that every 33 seconds someone dies from cardiovascular disease in the United States." (said at 0:04:15)
No published record matching the claim that someone dies from cardiovascular disease every 33 seconds in the United States was located; this does not prove the claim false.
Every cell in the human body except red blood cells synthesizes cholesterol.
"every cell in the body, with the exception of red blood cells, makes plenty of cholesterol." (said at 0:09:05)
No published record matching the claim that every cell in the human body except red blood cells synthesizes cholesterol was located; this does not prove the claim false.
Cholesterol contained in circulating lipoproteins accounts for about 10% of total body cholesterol.
"Those three lipoproteins constitute the amount of total cholesterol you have in the lipoproteins. We can come back to this idea because it's important: that represents about 10% of the total cholesterol in your body." (said at 0:11:40)
No published record matching the claim that cholesterol contained in circulating lipoproteins accounts for about 10% of total body cholesterol was located; this does not prove the claim false.
LDL particles can be synthesized de novo in addition to being formed from VLDL catabolism.
"And we also make LDL de novo, by the way, right?" (said at 0:28:28)
No published record matching the claim that LDL particles are synthesized de novo by direct hepatic secretion independently of VLDL catabolism was located; this does not prove the claim false.
Physiologic levels of LDL cholesterol and ApoB in humans are in the range of 10 to 30 mg/dL.
"Again, what we call physiologic levels of LDL cholesterol and ApoB are on the order of 10 to 30 milligrams per deciliter." (said at 0:32:59)
No published record matching the claim that physiologic levels of LDL cholesterol and ApoB in humans are in the range of 10 to 30 mg/dL was located; this does not prove the claim false.
Dr. Peter Libby from Brigham has argued that an ApoB level maintained below 20 to 30 mg/dL prevents the development of atherosclerosis.
"Yeah, so Peter Libby from the Brigham, who's one of the authorities on this topic, has has argued—and I reference him in my book—that if you had an ApoB level below about 30 milligrams per deciliter, 20 to 30 milligrams per deciliter, it wouldn't be possible to develop atherosclerosis." (said at 0:33:46)
No published record matching the claim that Dr. Peter Libby argued an ApoB level below 20 to 30 mg/dL makes it impossible to develop atherosclerosis was located; this does not prove the claim false.
Niemann-Pick C1-Like 1 (NPC1L1) transporters on enterocytes absorb sterols, including plant sterols and unesterified cholesterol, while esterified cholesterol cannot be absorbed directly and is excreted.
"So one of the transporters on them, it's called a Niemann-Pick C1-Like 1 transporter. It absorbs all of the sterols, and this is I use the word sterol very carefully to distinguish it here from just cholesterol. This is zymosterol and plant sterol which is, or animal sterol which is called cholesterol... Esterified cholesterol can't be absorbed, and most of the cholesterol we eat is esterified, that's why we just poop it out." (said at 0:55:30)
No published record matching the claim was located; this does not prove the claim false.
A blood lactate concentration of about 2 millimoles per liter marks the threshold where cellular energy production shifts away from maximal mitochondrial capacity.
"2 millimole is about the threshold beyond which you are now shifting away from the maximum capacity of the mitochondria to to, um, undergo this process." (said at 1:04:22)
No published record matching the claim that a blood lactate concentration of about 2 mmol/L marks the specific threshold where cellular energy production shifts away from maximal mitochondrial capacity was located; this does not prove the claim false.
Circulating phytosterols are more atherogenic and more prone to oxidation than cholesterol.
"because phytosterols are actually more atherogenic than cholesterol." (said at 1:26:18)
No published record matching the claim that circulating phytosterols are more atherogenic or more prone to oxidation than cholesterol was located; this does not prove the claim false.
At a fasting blood glucose level of 100 mg/dL, an adult has approximately 5 grams of glucose in total plasma circulation.
"Well, it means that in someone my size, in all of my plasma floating around all of my body, all of my blood, I have 5 grams of glucose." (said at 1:38:39)
No published record matching the claim that an adult has approximately 5 grams of glucose in total plasma circulation at a blood glucose level of 100 mg/dL was located; this does not prove the claim false.
A respiratory quotient (RQ) or respiratory exchange ratio (RER) of 0.7 indicates 100% fat oxidation, 0.85 indicates roughly 50% fat and 50% glucose oxidation, and 1.0 or above indicates 100% carbohydrate oxidation.
"When that ratio is 0.7, you are 100% fat oxidizing. When that ratio is 0.85, it's about 50/50. When that ratio is 1 and above, you're all carbohydrate." (said at 2:04:50)
No published record matching the claim was located; this does not prove the claim false.
Mammography has an approximate sensitivity of 90% and specificity of 85%.
"mammography has a sensitivity of about 90% and a specificity of about 85%" (said at 2:21:03)
No published record matching the claim that mammography has an approximate sensitivity of 90% and specificity of 85% was located; this does not prove the claim false.
Both men and women reach peak bone mineral density in their early 20s.
"the truth of it is both men and women hit peak bone density in their early 20s." (said at 2:37:55)
No published record matching the claim that both men and women reach peak bone mineral density in their early 20s was located; this does not prove the claim false.
The human body naturally limits cutaneous vitamin D3 synthesis from sunlight to prevent toxicity.
"your body regulates how much vitamin D3 is converted or is released into bloodstream and converted into 25-hydroxyvitamin D at the level of sun exposure. So at a certain level you're not making the vitamin D3 when you've gotten so much of it. That's how you avoid toxicity, right?" (said at 5:07:16)
No published record matching the claim that the human body naturally limits cutaneous vitamin D3 synthesis from sunlight to prevent toxicity was located; this does not prove the claim false.
Standard clinical blood pressure measurement protocol requires placing the automated cuff 2 inches above the elbow at the level of the right atrium.
"the cuff is 2 in above uh the elbow, and um the cuff is right at the level of the right atrium." (said at 3:37:00)
No published record matching the claim that standard clinical blood pressure measurement protocol requires placing the automated cuff 2 inches above the elbow at the level of the right atrium was located; this does not prove the claim false.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.