FoundMyFitness · 2021-11-02 · Rhonda Patrick (host), Ashley Mason
Dr. Ashley Mason on Sauna Use for Depression, Conquering Insomnia, and Mindfully Breaking Bad Habits
39 research-tied claims examined: 1 overstated 2 context 34 supported 2 unverified
2 No source found (not proven false)
Pretreatment with high-dose EPA omega-3 fatty acids prevents the development of depressive symptoms induced by lipopolysaccharide injection in healthy individuals.
"people were given a high dose of EPA, which is one of the marine omega-3 fatty acids that's very potent at negating inflammation, and the people that were given that and injected with lipopolysaccharide didn't experience the depressive symptoms." (said at 0:15:20)
No published record matching the claim that pretreatment with high-dose EPA omega-3 fatty acids prevents lipopolysaccharide-induced depressive symptoms in healthy humans was located; this does not prove the claim false. While clinical trials have investigated omega-3 fatty acids (specifically EPA) for the prevention of cytokine-induced depression in other experimental paradigms (such as interferon-alpha treatment in hepatitis C patients) and animal models have evaluated EPA against lipopolysaccharide challenges, a human trial demonstrating that high-dose EPA prevents depressive symptoms following lipopolysaccharide injection in healthy volunteers was not identified in the published literature.
A review by Janssen and Raison found that whole-body hyperthermia protocols with a longer duration spent reaching peak body temperature showed larger effect sizes in depression score reduction.
"in a recent paper that actually incidentally Janssen and Raison had written together, they reviewed some of the studies that exist looking at whole-body hyperthermia for depression. And one of the things they noted is that the effect sizes of the change in depression from before to after the intervention—in other words, the size of the reduction in depression—was higher if people spent more time getting to that peak temperature." (said at 0:27:13)
No published record matching a review by Janssen and Raison that found whole-body hyperthermia protocols with longer durations spent reaching peak body temperature produce larger effect sizes in depression score reduction was located; this does not prove the claim false. While Janssen, Raison, and colleagues have published trials demonstrating the antidepressant effects of whole-body hyperthermia (such as JAMA Psychiatry 2016), an indexed review specifically analyzing effect sizes as a function of the rate or duration of heating to peak temperature was not found.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.