Yeast cells placed in a glucose medium shift from oxidative phosphorylation to glycolysis by destroying most of their mitochondria through mitophagy.
"The easiest example is yeast that you suddenly place in a glucose-containing medium to allow for the fermentation of glucose in wine or beer production. So these yeast cells don't need much oxidative phosphorylation and they essentially rely during the process on glycolysis. So they adapt to this change by destroying most of their mitochondria by mitophagy." (said at 0:33:32)
The claim states that transferring yeast to a glucose-containing medium causes the cells to adapt by destroying most of their mitochondria through mitophagy. In Saccharomyces cerevisiae, high-glucose conditions actually repress and suppress mitophagy (for example, by maintaining low expression of the essential mitophagy receptor Atg32). Conversely, mitophagy is induced by glucose starvation, carbon depletion (such as ethanol depletion), or stationary phase growth, rather than by glucose exposure.
- contradicts: Analysis of autophagy activated during changes in carbon source availability in yeast cell… (The Journal of biological chemistry 2019)
"Furthermore, we found that mitophagy is induced by ethanol depletion." (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 lead… (Autophagy 2020)
"Overall, we conclude that Paf1C maintains mitophagy at a low level through binding the promoter of the ATG32 gene in glucose-rich conditions. Dissociation of Paf1C from ATG32 leads to the increased expression of this gene, and mitophagy induction upon glucose starvation." (abstract, conclusions, passage verified)
pubmedfull study (doi)