HoldsUp

FoundMyFitness · 2017-10-30 · Rhonda Patrick (host), Satchidananda Panda

Dr. Satchin Panda on Practical Implementation of Time-Restricted Eating & Shift Work Strategies

62 claims checked against research: 1 contradicted 2 overstated 3 needing context 53 supported 3 unverified

3

Needs context

1:07:15Satchidananda Pandaneeds contextvery low

In mouse partial hepatectomy models, mice operated on in the evening recover significantly faster than mice operated on in the daytime.

"And in mouse experiments, at least, if partial hepatectomy is done in the evening, then those mice recover much faster than those where the hepatectomy was done in the daytime." (said at 1:07:15)

Circadian rhythmicity influences hepatocyte cell cycle progression and liver regeneration after partial hepatectomy in mice. Regenerating liver hepatocytes exhibit pronounced diurnal oscillations in DNA synthesis, mitotic activity, and lipid accumulation, with peaks in cell proliferation tied to the nocturnal active phase and circadian clock genes such as Bmal1. However, the literature does not demonstrate a generalized finding that mice operated on in the evening recover substantially faster overall in liver mass or survival compared to daytime surgery; rather, the time of surgery aligns the post-hepatectomy regenerative waves with endogenous circadian gating of S-phase and M-phase entry.

1:09:10Rhonda Patrick (host)needs contextlow

Women who fast overnight for at least 13 hours have an approximately 36% lower risk of breast cancer recurrence.

"And that also jibes with another piece of data that came from Ruth Patterson's group, that women who fast for 13 hours overnight are protected from breast cancer. They have like a 36% lower breast cancer recurrence." (said at 1:09:10)

A prospective cohort study led by Ruth Patterson's group (analyzing 2,413 women from the Women's Healthy Eating and Living study) investigated nightly fasting duration and breast cancer recurrence. The authors found that fasting fewer than 13 hours per night was associated with a 36% increased hazard of breast cancer recurrence compared to fasting 13 or more hours per night (hazard ratio 1.36; 95% CI, 1.05–1.76). While the host accurately identifies the study group, the 13-hour threshold, and the 36% figure, the statistical relationship is slightly inverted: an HR of 1.36 for shorter fasting translates to roughly a 26% lower hazard of recurrence for women fasting 13 or more hours (1 - 1/1.36 ≈ 0.265). Furthermore, this evidence is observational rather than randomized.

1:15:45Satchidananda Pandaneeds contextlow

The Ruth Patterson breast cancer recurrence study permitted black coffee and tea during the 13-hour overnight fasting window.

"Well, at the same time, we know going back to the study that we discussed with Patterson study that did not consider coffee as food. So when they considered 13 hours overnight fasting, that 13 hours actually included coffee and tea." (said at 1:15:45)

The study referenced (Marinac, Patterson et al., published in JAMA Oncology in 2016) was an observational cohort analysis of 2,413 breast cancer survivors in the Women's Healthy Eating and Living (WHEL) study, rather than an interventional trial. Nightly fasting duration was estimated using 24-hour dietary recalls by calculating the time between the last food/caloric consumption in the evening and the first in the morning. Under standard dietary recall coding, non-caloric beverages (such as black coffee and plain tea) are not coded as caloric eating occasions and therefore did not terminate the calculated fasting interval. The claim is broadly accurate in describing how fasting duration was defined, but frames an observational data-coding methodology as an interventional study protocol.

  • context: Prolonged Nightly Fasting and Breast Cancer Prognosis. (JAMA oncology 2016) · cited 184x in the literature
    "Data were collected from 2413 women with breast cancer but without diabetes mellitus who were aged 27 to 70 years at diagnosis and participated in the prospective Women's Healthy Eating and Living study between March 1, 1995, and May 3, 2007. Data analysis was conducted from May 18 to October 5, 2015. Nightly fasting duration was estimated from 24-hour dietary recalls collected at baseline, year 1, and year 4." (abstract, methods, passage verified)
    pubmedfull study (doi)

Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.