During DNA damage, yeast sirtuins relocate from their normal genomic loci to assist in DNA repair, which leads to sterility by disrupting mating-type silencing.
"these sirtuins, these enzymes, normally they control a variety of cell functions including mating, and during aging they get distracted primarily by DNA damage, and they leave the place on the chromosome and go and help repair the DNA. But in doing so, and while they're distracted, the yeast cells are sterile. And that was the big finding in the 1990s." (said at 0:06:13)
No published record matching the claim that yeast sirtuin redistribution during DNA damage causes sterility by disrupting mating-type silencing was located; this does not prove the claim false.