How Omega-3s May Slow Biological Aging (New Evidence)

In a 2-year trial in patients with mild cognitive impairment, 2 grams of omega-3 daily improved cognitive and executive function, lowered plasma amyloid-beta, and increased markers of neuronal autophagy compared to placebo.

"These patients had uh mild cognitive impairment and they took 2 grams a day of omega-3 for two years, and after the two years they had improvements in cognitive function, executive function, um and importantly, they actually had lower plasma biomarkers of Alzheimer's disease. So they had lower amyloid-beta in their in in their plasma, but they also had increased markers of neuronal autophagy." (said at 0:33:25)

No published record matching a 2-year randomized trial in patients with mild cognitive impairment where 2 grams daily of omega-3 supplementation improved executive function, reduced plasma amyloid-beta, and increased markers of neuronal autophagy compared to placebo was located; this does not prove the claim false.

In physically inactive people, muscle mass declines by an average of 8% per decade after peak mass in their 20s or 30s, and by 15% per decade after age 70.

"we reach our peak muscle mass at around the age 20 to 30, then we start to lose on average about 8% per decade after that... The average person then when they hit the age of 70 starts to lose 15% per decade." (said at 0:37:55)

No published record matching the specific rates of muscle mass loss (an average decline of 8% per decade after peak mass in the 20s or 30s, accelerating to 15% per decade after age 70 in inactive individuals) was located; this does not prove the claim false.

By age 70 to 80, the average person has retained approximately 60% to 80% of the muscle mass they had at age 30.

"As someone reaches the age of 70 to 80 years old, they have about 60 to 80% of the muscle mass they had when they were 30." (said at 0:38:27)

No published record matching the specific claim that the average person retains approximately 60% to 80% of their age-30 muscle mass by age 70 to 80 was located; this does not prove the claim false.

Injecting healthy individuals with postprandial levels of LPS increases inflammatory biomarkers, depressive symptoms, and social withdrawal, but prior supplementation with omega-3 prevents these depressive symptoms and blunts the inflammatory response.

"there have been studies that have injected LPS at a normal level that you would find being released in the circulation after a meal... and injecting the LPS into those individuals increases their inflammatory biomarkers, but it also increases depressive symptoms. It it increases um, you know, social withdrawal as well. Within that same study, if individuals were given an omega-3 supplement before they were injected with LPS, their inflammatory markers weren't going up as much and they weren't getting the depressive symptoms." (said at 0:49:40)

No published record matching the claim that prior supplementation with omega-3 fatty acids prevents depressive symptoms and social withdrawal following an in vivo low-dose lipopolysaccharide (LPS) challenge in healthy humans was located; this does not prove the claim false. Published human trials investigating omega-3 supplementation and low-dose endotoxin (LPS) challenges in healthy human participants (such as PMID 30575798 and PMID 36907552) have evaluated plasma, serum, and triglyceride-rich lipoprotein oxylipin profiles, pro-resolving lipid mediator clusters, and metabolic/inflammatory responses, but these studies did not report evaluations of depressive symptoms or social withdrawal associated with omega-3 pre-treatment in humans.

• context: Identification of specialized pro-resolving mediator clusters from healthy adults after in… (Scientific reports 2018) · cited 108x in the literature

  "In healthy adults given ω-3 supplementation, the plasma concentration of the SPM cluster (RvE1, RvD1, LXB 4 , 18-HEPE, and 17-HDHA) peaked at two hours post endotoxin challenge." (abstract, results, passage verified)

  pubmedfull study (doi)
• context: Effect of omega-3 ethyl esters on the triglyceride-rich lipoprotein response to endotoxin … (Journal of lipid research 2023) · cited 8x in the literature

  "In conclusion, this study shows that TGRL fatty acid and oxylipin composition changes following endotoxin challenge. P-OM3 alters the TGRL response to endotoxin challenge by increasing availability of ω-3 oxylipins for resolution of the inflammatory response." (abstract, conclusions, passage verified)

  pubmedfull study (doi)