FoundMyFitness · 2022-08-24 · Rhonda Patrick (host), George Church
George Church, PhD: Rewriting Genomes to Eradicate Disease and Aging
57 research-tied claims examined: 3 overstated 3 context 42 supported 5 corroborated online 4 unverified
5 Corroborated by web sources
Around 2009, single-stranded DNA-annealing proteins (SSAPs / Lambda Red) were used to create libraries of billions of edited cells in a single day by one person.
"Another one that dates back two decades before CRISPR is SSAPs, or Lambda Red, as it's sometimes called. It's a way of getting precise editing, and that's what we actually used around 2009 to make libraries of billions of edited cells in a day by a single person." (said at 0:38:57)
No published record matching the claim regarding the use of single-stranded DNA-annealing proteins (SSAPs / Lambda Red) in 2009 to create libraries of billions of edited cells in a single day by one person was located; this does not prove the claim false.
corroborated by web sourcesIn 2009, researchers developed Multiplex Automated Genome Engineering (MAGE) using bacteriophage Lambda Red single-stranded DNA-annealing proteins. Scientific publications document that this method allowed a single operator to generate billions of edited cellular variants in a day.
researchgate.netosti.govcenturyofbio.combiopharmconsortium.com
DNA molecular recording systems in living cells have been demonstrated at multiplex scales ranging from 60 to 24,000 edits.
"because it's a very compact recording device of the physiological states of every cell in the body. And we've shown this works sort of on the scale of 60 to 24,000, and that's probably our first effort at making a million edits will be in the form of these molecular flight recorders." (said at 0:47:55)
No published record matching the claim that DNA molecular recording systems in living cells have been demonstrated at multiplex scales ranging from 60 to 24,000 edits was located; this does not prove the claim false.
corroborated by web sourcesGeneticist George Church has reported developing multiplex genome editing and molecular recording systems in living cells operating at scales ranging from dozens of edits up to 24,000 edits per cell.
foundmyfitness.com
There are approximately 3,500 mosquito species, of which only about half a dozen major species transmit human malaria.
"Now there's a limited number of mosquitoes that carry, um, malaria, maybe half dozen major ones out of 3,500 species of mosquito." (said at 1:42:58)
No published record matching the claim that there are approximately 3,500 mosquito species with only about half a dozen major species transmitting human malaria was located; this does not prove the claim false.
corroborated by web sourcesPublic health and entomological authorities confirm that there are roughly 3,500 to 3,600 recognized mosquito species worldwide. While roughly 30 to 40 species within the *Anopheles* genus can transmit malaria to humans, the vast majority of transmission is driven by a small handful of primary species, largely within the *Anopheles gambiae* and *funestus* complexes.
wikipedia.orgup.ac.zatargetmalaria.orgmalariaworld.orgbritannica.com
George Church and colleagues encoded an entire book into DNA and generated approximately 70 billion copies.
"the book was encoded into DNA... So so I wrote did the book, made, you know, 70 70 billion copies" (said at 1:56:40)
No published record matching the claim that George Church and colleagues encoded an entire book into DNA and generated approximately 70 billion copies was located; this does not prove the claim false.
corroborated by web sourcesIn 2012, Harvard geneticist George Church and colleagues published research in the journal Science demonstrating that they had encoded Church's book, *Regenesis*, into DNA. The team synthesized approximately 70 billion copies of the book in DNA form to demonstrate high-density biological data storage.
harvard.eduicr.org
Researchers have recorded 2 terabytes of physiological data in vivo within one-billionth the mass of a mouse.
"we recorded, um, um, 2 terabytes of information in a mouse in one-billionth the mass of the mouse. So it's the one of the world's smallest recording devices: a billionth of a mouse can encode 2 terabytes." (said at 1:59:00)
No published record matching the claim that researchers recorded 2 terabytes of physiological data in vivo within one-billionth the mass of a mouse was located; this does not prove the claim false. While molecular and DNA recording systems (such as CRISPR-based DNA tape recorders) have been developed to log lineage and cellular events in living systems, published demonstrations operate on orders of magnitude far smaller than multiple terabytes of decoded physiological data.
corroborated by web sourcesGeneticist George Church and his research team have reported utilizing in vivo DNA data storage to record terabytes of biological and developmental information in nanograms of DNA, which corresponds to roughly one-billionth of a mouse's body mass.
nih.gov
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.