Looking At Microplastics & Inflammation’s Impact on Brain Health | Jack Auty

Smooth spherical microplastics do not trigger an inflammatory response in cultured immune cells, whereas irregularly milled microplastic fragments with sharp edges induce a strong inflammatory response.

"They weren't inflammatory and I was confused. I was like, why aren't these new microplastics inflammatory? Um but you look at them down the electron microscope, they're perfectly spherical, um these microplastics that you buy from the company, which is not what you get out in the wild... And when we did this, we found that we ended up with a more natural looking microplastic fragment which had edges and spikes and these were back to being incredibly inflammatory" (said at 0:27:45)

No published record matching the claim that smooth spherical microplastics do not trigger an inflammatory response in cultured immune cells while irregularly milled microplastic fragments with sharp edges induce a strong inflammatory response was located; this does not prove the claim false.

A study in Australia found that 40% of household dust is composed of microplastics.

"There've been several studies, one in Australia in fact that showed that 40% of household dust is microplastics." (said at 0:34:45)

No published record matching the claim that a study in Australia found that 40% of household dust is composed of microplastics was located; this does not prove the claim false.

Studies demonstrate that lung cancer receives less research funding because of societal stigma and victim-blaming associated with smoking history.

"And there's actually studies that show that lung cancer gets less research funding because people blame the people with lung cancer for getting lung cancer." (said at 0:43:34)

No published record matching the claim that lung cancer receives less research funding because of societal stigma and victim-blaming associated with smoking history was located; this does not prove the claim false.

Applying crushed garlic to the foot allows allicin to penetrate the skin barrier and enter systemic circulation such that it can be tasted on the tongue.

"if you crush garlic and rub it on your foot, because the smell of garlic is actually an oil called allicin, it can actually get up to your tongue and you will taste garlic if you rub it on your foot." (said at 0:33:20)

No published record matching the claim that rubbing crushed garlic on the foot allows allicin to enter systemic circulation and be tasted on the tongue was located; this does not prove the claim false. In vitro modeling demonstrates that organosulfur garlic compounds possess passive skin permeability (PMID 34616711, PMID 34713965), but direct application of raw crushed garlic to the skin presents a risk of severe chemical burns and skin irritation (PMID 30702643).

• context: Burns Due to Application of Raw Garlic to the Feet as a Home Remedy for Fever. (Pediatric emergency care 2019) · cited 4x in the literature

  "We present an illustrative case of unintentional burns to the feet of a 15-month-old child following the application of raw garlic as a home remedy for fever." (abstract, introduction, passage verified)

  pubmedfull study (doi)
• context: Permeability Data of Organosulfur Garlic Compounds Estimated by Immobilized Artificial Mem… (Frontiers in chemistry 2021) · cited 14x in the literature

  "The human gastrointestinal absorption (HIA), blood-brain barrier (BBB) permeation, and skin permeability were investigated through QSAR modeling, using several chemometric approaches." (abstract, methods, passage verified)

  pubmedfull study (doi)
• context: Development of topical patches releasing allicin using garlic extract. (Journal of cosmetic dermatology 2022) · cited 4x in the literature

  "The percentage of allicin diffused across cellulose membrane over 20 h from patch E (45 mg CP, 2 mL fresh garlic extract-equivalent to 60 mg allicin-and 1 mL of ethanol) was 79.94%. The flux and permeability coefficients were 2.62 mg/cm 2 /h and 0.52 cm/h, respectively, with an enhancement ratio of 2.60 times the reference patch M (mashed garlic)." (abstract, results, passage verified)

  pubmedfull study (doi)