38 claims checked against research: 1 overstated 1 needing context 29 supported 7 unverified
"And so activity in the default mode network is actually increased in depression, and here, a couple of the hubs are prefrontal cortex and posterior cingulate." (said at 0:27:28)
No published record matching the claim that default mode network activity is elevated in individuals with depression was located; this does not prove the claim false.
"personality theorists would tell you that doesn't happen. Those personality characteristics are locked in kind of from mid-20s. And if anything, openness decreases then across the lifetime." (said at 0:39:06)
No published record matching the claim that standard personality theory posits core personality traits become fixed from the mid-20s onwards and openness generally decreases across the lifespan was located; this does not prove the claim false.
"if we ask the clinicians that are closest to the volunteers to rate the probability of difficult experiences, their ability to predict that is almost none at all." (said at 0:51:33)
No published record matching the specific claim that clinicians closely supporting volunteers have near-zero predictive ability regarding which individuals will have difficult or challenging psilocybin experiences was located; this does not prove the claim false. While research has characterized challenging psilocybin experiences (such as via the Challenging Experience Questionnaire) and examined various baseline psychological predictors of acute drug effects, specific published trial data evaluating the predictive accuracy of clinicians' prior probability ratings were not identified.
"and at this point, we have treated over 260 people with psilocybin, we have experience of over 570 sessions with psilocybin." (said at 0:51:01)
No published record matching the specific cumulative tally of over 260 participants and more than 570 psilocybin sessions conducted at Johns Hopkins was located; this does not prove the claim false.
"And so people are screened out if they have any even second degree relative with history of psychotic disorder or bipolar disorder." (said at 0:49:12)
No published record matching the claim that Johns Hopkins psilocybin research protocols exclude participants with a second-degree relative with a history of psychotic or bipolar disorders was located; this does not prove the claim false.
"agonism of the kappa-opioid receptor had a feedback loop effect where it actually caused mu-opioid receptors, which bind to beta-endorphins, to become more sensitized to the endorphins. And so I read up on this, checked the literature and references, and found that indeed the agonism of it does actually cause mu-opioid receptors to become sensitized to endorphins" (said at 1:45:33)
No published record matching the claim that agonism of the kappa-opioid receptor causes mu-opioid receptors to become sensitized to endorphins was located; this does not prove the claim false.
"There's evidence of probably almost 200 species of psilocybin mushrooms and those are used... have been used around the world." (said at 1:52:34)
No published record matching the claim that there are nearly 200 known species of psilocybin-containing mushrooms worldwide was located; this does not prove the claim false.