Stop the "Toxic" Estrogen Loop: The Secret to Safer HRT

Phenethyl isothiocyanate (PEITC) from watercress acts synergistically with sulforaphane to stimulate NRF2 five times more than sulforaphane alone.

"And then we add one from watercress. It's called PEITC, phenethyl isothiocyanate. Name's not important, but what is important is that um and this is in the literature and we've shown it in our own tests, it stimulates NRF2 synergistically with sulforaphane. So, 1 + 1 = 5. So, it turns on NRF2 five times more than sulforaphane alone." (said at 0:14:20)

No published record matching the claim that phenethyl isothiocyanate (PEITC) acts synergistically with sulforaphane to stimulate NRF2 five times more than sulforaphane alone was located; this does not prove the claim false. While both sulforaphane and PEITC are well-documented in vitro and ex vivo activators of Nrf2 and downstream phase II antioxidant enzymes, published studies demonstrating a specific 5-fold synergistic co-activation of Nrf2 by this combination were not identified in the peer-reviewed literature.

• context: Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidati… (Pharmacological research 2013) · cited 65x in the literature

  "Mechanistic cell culture studies revealed SFN and PEITC to increase Nrf2 activity and Nrf2-dependent gene expression (γGCS, HO-1, NQO1); this was paralleled in human full skin mRNA." (abstract, results, passage verified)

  pubmedfull study (doi)

Glyphosate causes leaky gut by opening intestinal epithelial tight junctions.

"glyphosate's known to cause leaky gut opening the tight junctions. And so, he did this cell culture study opening with opening tight junctions with glyphosate, but then giving you know broccoli sulforaphane and showing that it's protective against that." (said at 0:28:54)

No published record matching the claim that glyphosate opens intestinal epithelial tight junctions to cause leaky gut and that broccoli-derived sulforaphane protects against glyphosate-induced tight junction disruption in cell culture was located; this does not prove the claim false.

Sulforaphane protects intestinal epithelial tight junctions from damage caused by glyphosate.

"And so, he did this cell culture study opening with opening tight junctions with glyphosate, but then giving you know broccoli sulforaphane and showing that it's protective against that." (said at 0:28:54)

No published record matching a cell culture study showing that sulforaphane protects intestinal tight junctions specifically against glyphosate-induced disruption was located; this does not prove the claim false. While sulforaphane has been investigated in in vitro models for protecting intestinal epithelial integrity against various inflammatory and oxidative stressors (such as TNF-α), direct published evidence testing sulforaphane against glyphosate in tight-junction assays has not been identified in the peer-reviewed biomedical literature.

Sulforaphane activates NRF2 and inhibits NF-κB via covalent modification of reactive cysteine residues.

"the way it affects NF-κB is the same way it activates um NRF2. It's through a reactive cysteine modification, the covalent change that happens." (said at 0:54:41)

No published record matching the claim that sulforaphane activates NRF2 and inhibits NF-κB through covalent modification of reactive cysteine residues was located; this does not prove the claim false.

A 10 mg dose of sulforaphane reduces interleukin-6 (IL-6) levels by 30% within 24 hours.

"two capsules so 10 mg of sulforaphane um decreases IL-6 so uh so an inflammatory marker 30% in 24 hours." (said at 0:39:41)

No published record matching the claim that a 10 mg dose of sulforaphane decreases interleukin-6 (IL-6) levels by 30% within 24 hours was located; this does not prove the claim false. While sulforaphane has been investigated for its antioxidant and anti-inflammatory properties in preclinical models and small human trials, clinical data demonstrating this specific acute percentage reduction at a 10 mg dose in humans are lacking.

Polysorbate 80 strips lipopolysaccharide (LPS) off the outer membrane of gram-negative bacteria such as Salmonella.

"if you take um uh one like salmonella and you want to get a really potent um immune reaction, you mix that with polysorbate 80 and it strips the strips the LPS off the surface and then you can use that as a stimulant" (said at 1:17:20)

No published record matching the claim that mixing Salmonella with polysorbate 80 strips lipopolysaccharide (LPS) from the bacterial surface to create a potent immune stimulant was located; this does not prove the claim false. While detergents and surfactants can interact with bacterial outer membranes, standard biochemical extraction of LPS typically uses methods such as hot phenol-water extraction or specific organic solvent protocols rather than simple mixing with polysorbate 80.

Clinical studies show black cohosh acts on serotonin and dopamine pathways in the hypothalamus to aid in temperature regulation and mood.

"the black cohosh is uh clinical studies showing that it it um works on serotonin, dopamine in the hypothalamus. And so, those are sort of the the uh temperature regulation and mood um centers. So, it helps helps with that." (said at 1:19:35)

No published record matching the claim that clinical studies show black cohosh acts on serotonin and dopamine pathways in the hypothalamus to aid in temperature regulation and mood was located; this does not prove the claim false.

Certain highly bioavailable commercial curcumin supplement formulations are composed of approximately 97% detergent (polysorbate 80) and only 3% curcumin.

"Yeah, and the one a lot of doctors say is the most bioavailable actually is 97% um detergent and 3% curcumin." (said at 1:16:12)

No published record matching the claim that certain highly bioavailable commercial curcumin supplement formulations contain approximately 97% polysorbate 80 detergent and 3% curcumin was located; this does not prove the claim false.