The Right Way to Use HRT, GLP-1s & Peptides | Dr. Ksenia Petrushkina

Semax and Selank are available over the counter as nasal sprays in Russia.

"Semax and Selank in Russia, over-the-counter medication. You can just buy the nasal sprays." (said at 0:25:28)

No published record matching the claim that Semax and Selank are approved specifically as over-the-counter medications in Russia was located; this does not prove the claim false. While scientific reviews document that Semax and Selank are synthetic peptide formulations developed in the Russian Federation and commonly administered via intranasal delivery, indexed biomedical literature does not document their precise domestic regulatory prescription status (over-the-counter vs. prescription-only).

Intravenous administration of 500 to 750 mg of NAD stopped flare-ups in a patient with psoriatic arthritis.

"Also, I have a patient with psoriatic arthritis whom I gave 500 mg of NAD, I think even 750 once for 3 weeks, and his flare-up stopped." (said at 0:30:45)

No published record matching the claim that intravenous administration of 500 to 750 mg of NAD stopped flare-ups in a patient with psoriatic arthritis was located; this does not prove the claim false.

Excess exogenous testosterone converts to DHT, leading to benign prostatic hyperplasia and hair loss, and aromatizes to estrogen, causing gynecomastia.

"It's going to convert to DHT. It's going to aromatize to estrogen. And then you need now finasteride to bring the DHT down because high DHT equals BPH—that's bad for your prostate, and your hair falls out, and you're going to lose your hair—and anastrozole because you don't want to have man boobs, but your estrogen goes up." (said at 0:36:49)

No published record matching the claim was located; this does not prove the claim false.

High-dose or long-term anabolic steroid use can lead to the formation of large hepatic cysts or vascular lesions that can rupture and cause severe internal hemorrhage.

"I had one patient who had been on so many anabolics, he actually ended up—he was a powerlifter—he ended up with a massive cyst in his liver that ruptured while he was on the podium lifting like a massive deadlift. And he just about bled out and died right there in the middle of the competition." (said at 0:40:46)

No published record matching the specific case of a powerlifter suffering a hepatic cyst or vascular lesion rupture during a deadlift competition while using anabolic steroids was located; this does not prove the claim false. Published medical literature documents that anabolic-androgenic steroid use can lead to vascular lesions such as peliosis hepatis and hepatic adenomas, which carry a risk of rupture and severe internal hemorrhage.

• context: Spontaneous liver rupture in a patient with peliosis hepatis: a case report. (World journal of gastroenterology 2009) · cited 54x in the literature

  "We suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma, especially in patients under prolonged synthetic anabolic steroid medication. The possibility of a potentially life-threatening complication of massive intra-abdominal bleeding should also be considered." (abstract, conclusions, passage verified)

  pubmedfull study (doi)
• context: Liver tumours. (Bailliere's clinical gastroenterology 1988) · cited 66x in the literature

  "Anabolic-androgenic steroids stand out as the major cause of peliosis, but liver cell tumours induced by them seem to be adenomas and not carcinomas as originally suggested. The effect that both oral contraceptives and anabolic-androgenic steroids have on liver vasculature is of great clinical importance as the most important complication of liver tumours is rupture, leading to life-threatening haemorrhage." (abstract, passage verified)

  pubmedfull study (doi)

Injectable GHK-Cu (copper peptide) can induce acute hypersensitivity reactions, severe allergic responses, and anaphylaxis.

"And just the anaphylaxis. I mean, this like GHK-Cu, one of my buddies who is well-versed in peptides, a clinician, he was like, "I've seen anaphylaxis with GHK-Cu more times than I'd like to count."" (said at 0:59:37)

No published record matching the claim that injectable GHK-Cu induces frequent anaphylaxis or acute severe hypersensitivity reactions was located; this does not prove the claim false. While injectable GHK-Cu is widely used in off-label and unregulated settings, published clinical literature on GHK-Cu is predominantly limited to in vitro models, animal studies, and topical cosmetic applications. Systematic and narrative reviews evaluating therapeutic peptides highlight a general lack of rigorous human clinical trial data and systematic adverse event reporting for unapproved injectable peptide formulations, but published case reports or observational series documenting confirmed GHK-Cu-induced anaphylaxis are absent.