Mark Hyman, MD · 2026-08-12 · Mark Hyman (host), Tyna Moore

What We Got Wrong About GLP-1s (And What's Actually Right)

44 research-tied claims examined: 3 contradicted 4 overstated 6 context 24 supported 7 unverified

7

No source found (not proven false)

0:11:58Tyna Mooreunverifiedvery low

Skeletal muscle mass accounts for at most 25% to 40% of total lean mass measured on a DEXA scan.

"Your muscle mass only makes up maybe at most 25 to 40% of that overall lean mass number." (said at 0:11:58)

No published record matching the claim that skeletal muscle mass accounts for at most 25% to 40% of total lean mass measured on a DEXA scan was located; this does not prove the claim false.

0:14:01Mark Hyman (host)unverifiedvery low

Cellular NAD+ levels decrease by approximately 50% by middle age.

"The problem is NAD+ levels drop by about 50% by the time you hit middle age." (said at 0:14:01)

No published record matching the claim that cellular NAD+ levels drop by approximately 50% by middle age was located; this does not prove the claim false.

0:38:40Tyna Mooreunverifiedvery low

Studies demonstrate that patients on higher doses of GLP-1 receptor agonists have reduced physical movement.

"Patients on higher doses, the study came out showing they just don't move around as much because I think it's because of that." (said at 0:38:40)

No published record matching the claim that studies demonstrate patients on higher doses of GLP-1 receptor agonists have reduced physical movement was located; this does not prove the claim false.

0:42:50Tyna Mooreunverifiedvery low

A 2024 study in Gastroenterology found no statistically significant increase in pancreatitis, bowel obstruction, or gallbladder inflammation among GLP-1 receptor agonist users.

"but this new study came out in Gastroenterology in 2024, and it was a better done study, and the finding was no significant increase in pancreatitis, bowel obstruction, or gallbladder inflammation." (said at 0:42:50)

No published record matching a 2024 study in Gastroenterology reporting no statistically significant increase in pancreatitis, bowel obstruction, or gallbladder inflammation among GLP-1 receptor agonist users was located; this does not prove the claim false.

0:58:50Tyna Mooreunverifiedvery low

A May 2024 study evaluating 49 online telemedicine GLP-1 websites found that 17 sold compounded medication, 5 sold branded only, 27 sold both, only 2 required blood work, only 13 required a video visit, and only 3 required a phone call.

"And then there was a study that came out in May of 2024. I don't know if you saw it, but they did a study. They looked at 49 different online telemedicine GLP-1 websites... Seventeen sold compounded, only five sold branded only, and 27 sold both. Two required blood work... only 13 required a video visit, and three required a call." (said at 0:58:50)

No published record matching the May 2024 study evaluating prescribing requirements and product offerings across 49 direct-to-consumer telemedicine GLP-1 websites was located; this does not prove the claim false. The cited findings may originate from an industry, regulatory, or investigative report rather than a peer-reviewed biomedical journal indexed in standard medical databases.

1:07:11Tyna Mooreunverifiedvery low

Alcohol poisons mitochondria, and mitochondrial impairment is part of the reason people struggle to lose weight.

"It's also a poison. It's poisoning your mitochondria, and your mitochondria being poisoned are part of the reason why you can't lose weight." (said at 1:07:11)

No published record matching the claim that alcohol-induced mitochondrial toxicity is a direct causal mechanism preventing weight loss was located; this does not prove the claim false.

1:09:13Mark Hyman (host)unverifiedvery low

Fasting serum insulin is included on fewer than 1% of laboratory test orders processed by Quest Diagnostics.

"and I just talked to the lab guys at Quest, who is our Function Health partner, and I said, "What percentage of tests that you get are including insulin on orders?" He said, "Less than 1%."" (said at 1:09:13)

No published record matching the claim that fasting serum insulin is included on fewer than 1% of laboratory test orders processed by Quest Diagnostics was located; this does not prove the claim false.

Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.