Gallbladder congestion is associated with heart palpitations, and TUDCA can help alleviate this symptom.
"there's definitely this cross over where people get palpitations with having problems with the gallbladder in which case you want to take TUDCA. That's a good remedy and that just may open up the bile ducts to allow you to um not have that irritation on the heart." (said at 0:16:27)
The host's statement bundles two assertions: (1) gallbladder disease can cause heart symptoms like palpitations, and (2) TUDCA treats gallbladder-induced heart palpitations by opening bile ducts to relieve cardiac irritation. While published case reports recognize the 'cardio-biliary reflex' (Cope's sign), wherein gallbladder disease triggers vagal signals that cause cardiac rhythm disturbances or arrhythmias (PMID: 41216055, PMID: 35165631), there is no published clinical evidence demonstrating that TUDCA (tauroursodeoxycholic acid) relieves cardiac palpitations or treats heart symptoms secondary to gallbladder congestion. Studies on TUDCA show it modifies bile acid composition and gallbladder volume (PMID: 8782006, PMID: 36353477), but no published record matching its use to alleviate cardiac palpitations was located.
- context: Acute Calculous Cholecystitis With Sinus Bradycardia: Cope's Sign Encountered. (Cureus 2022)
"Nonspecific electrocardiographic changes and arrhythmias can occur in acute cholecystitis and gallbladder disease that can confuse the treating physician leading to extensive cardiac workup." (abstract, passage verified)
pubmedfull study (doi) - context: Effects of oral tauroursodeoxycholic acid and/or intestinal probiotics on serum biochemica… (Frontiers in pharmacology 2022)
"The use of intestinal probiotics alone can maximise the reverse development of bile composition in patients with cholecystolithiasis compared with TUDCA alone and a combination of TUDCA and intestinal probiotics, thereby reducing gallstone formation." (abstract, conclusion, passage verified)
pubmedfull study (doi) - context: The Cardio-Biliary Reflex in Gallbladder Disease: A Case Report and Literature Review. (Cureus 2025)
"This reflex is a well-recognized physiological response in which gallbladder pathology triggers vagal nerve signals, potentially causing significant alterations in cardiac rhythm and often mimicking primary heart conditions." (abstract, passage verified)
pubmedfull study (doi) - context: Tauroursodeoxycholic acid, ursodeoxycholic acid and gallbladder motility in gallstone pati… (The Italian journal of gastroenterology 1996)
"Therapeutic doses of tauroursodeoxycholic acid or ursodeoxycholic acid do not acutely modify postprandial gallbladder emptying in either healthy subjects or gallstone patients. Chronic treatment with either bile salts results in an increase in fasting gallbladder volume without interfering with the extent of postprandial gallbladder emptying." (abstract, passage verified)
pubmed