Oxalate nephropathy and intravenous vitamin C.
Level 4 - case-series / case-control
Individual clinical case report
PubMed 23548555 · doi:10.1053/j.ajkd.2013.01.025
What was done
This case report describes an individual with underlying systemic lupus erythematosus who presented with acute kidney injury and was diagnosed with acute oxalate nephropathy following recent administration of intravenous vitamin C.
What was found
The abstract reports no numerical values, specific dosages, or quantitative clinical measurements. It notes that the patient presented with acute kidney injury, normal serologic studies, and a renal biopsy demonstrating acute tubular injury with characteristic polarizable crystals within the tubular lumen and epithelial cytoplasm following intravenous vitamin C exposure.
Why it matters
It highlights high-dose or intravenous vitamin C as a potential secondary trigger for calcium oxalate crystal deposition and acute tubular injury in patients with predisposing conditions.
Limits
This is an uncontrolled single-patient case report (n = 1), preventing any assessment of incidence, risk factors, or definitive causality. The abstract does not report the dose, frequency, or duration of intravenous vitamin C administered, nor baseline renal function or clinical recovery.
Cited by
- supports High doses of intravenous vitamin C have been observed to cause oxalate nephropathy in patients with preexisting kidney impairment.