Touboul · Frontiers of neurology and neuroscience 2015 · narrative review · n=?

Intima-media thickness of carotid arteries.

Cited 19 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review without systematic search or original data

PubMed 25531661 · doi:10.1159/000366234 · record verified 2026-08-27

What was done

Narrative review describing carotid intima-media thickness (CIMT) measurement methodologies, sources of technical variability (patient, device, operator, and software), the updated Mannheim consensus criteria for distinguishing CIMT from plaques, and clinical indications for cardiovascular risk stratification.

What was found

The abstract provides no numerical data, effect sizes, or statistical metrics. It describes CIMT as a validated predictive marker for plaque occurrence and major cardiovascular events, primarily indicated for detecting coronary heart disease risk in intermediate-risk patients.

Why it matters

Highlights the necessity of certified operators and standardized protocols (such as the Mannheim consensus) to reliably quantify early atherosclerosis in clinical practice and trials.

Limits

Narrative review with no primary empirical data or systematic search methodology reported. The abstract provides no quantitative diagnostic accuracy metrics or statistical outcomes.

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