Targeting One-Hour Postmeal Glucose: Is It Time for a Paradigm Switch in Diabetes Management?
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and observational literature without systematic review methodology
PubMed 28665142 · doi:10.1089/dia.2017.0135
What was done
This narrative review summarizes cellular, animal, and human literature examining the pathophysiological effects and predictive value of 1-hour postload and postmeal glucose levels compared to conventional 2-hour targets in diabetes and cardiovascular risk management.
What was found
The abstract reports no numerical data, effect sizes, or primary statistics. It qualitatively summarizes that 1-hour postload glucose is a stronger predictor of developing diabetes and an independent cardiovascular risk factor compared to 2-hour glucose, and that 1-hour glucose spikes drive oxidative stress, endothelial dysfunction, inflammation, and thrombosis.
Why it matters
Targeting 1-hour rather than 2-hour postprandial glucose could alter glycemic guidelines and therapeutic monitoring strategies in diabetes care.
Limits
This is a narrative review with no systematic search methodology reported in the abstract and no new primary data. Specific diagnostic cutoffs, quantitative metrics, and clinical trial outcomes are absent.
Cited by
- context Postprandial blood glucose spikes above 140 mg/dL cause arterial damage.