Patrick · Experimental gerontology 2021 · narrative review · n=?

Sauna use as a lifestyle practice to extend healthspan.

Cited 73 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review summarizing mechanistic, interventional, and observational literature without systematic review methodology.

PubMed 34363927 · doi:10.1016/j.exger.2021.111509 · record verified 2026-08-30

What was done

This narrative review synthesizes evidence from observational cohort studies, interventional trials, and mechanistic research regarding sauna bathing (short-term passive heat exposure typically ranging from 45 °C to 100 °C). The authors outline the physiological, neuroendocrine, cardiovascular, and cytoprotective responses to heat stress, describe hormetic adaptation, and summarize reported health outcomes and safety considerations.

What was found

The abstract reports no quantitative metrics, effect sizes, confidence intervals, or specific sample sizes. It reports qualitatively that repeated sauna use triggers mild hyperthermia and adaptive hormetic responses, and notes that large prospective population-based cohort studies have identified strong dose-dependent links between regular sauna bathing and reduced morbidity and mortality.

Why it matters

Heat exposure via sauna bathing represents a non-pharmacological lifestyle intervention that may improve cardiovascular and cellular resilience, offering a potential adjunct for extending healthspan.

Limits

The paper is a narrative review rather than a formal systematic review or meta-analysis. Observational cohort data cited are susceptible to residual confounding and healthy-user bias (individuals able and choosing to use saunas regularly may have better baseline health status). No specific quantitative outcomes, protocol parameters, or risk figures are provided in the abstract.

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