Systematic review and meta-analysis of diagnostic test accuracy (DTA) studies: the role of cerebral perfusion imaging in prognosis evaluation of mild cognitive impairment.
Level 1 - systematic review of randomized trials
Systematic review and meta-analysis of diagnostic test accuracy studies
PubMed 35249345 · doi:10.21037/apm-21-3916
What was done
Authors conducted a systematic review and meta-analysis of diagnostic test accuracy studies evaluating cerebral perfusion imaging (FDG-PET, SPECT, and structural MRI) for the prognostic assessment of mild cognitive impairment (MCI). Databases including PubMed, Medline, and CNKI were searched up to December 30, 2020. Analyses were conducted using Review Manager.
What was found
A total of 16 references were included. The sensitivity and specificity of FDG-PET imaging were reported to be significantly higher than those of SPECT and MRI (P < 0.05). sROC curves showed no shoulder-arm distribution and no threshold effect. The abstract provides no specific point estimates or confidence intervals for sensitivity, specificity, or summary AUC values.
Why it matters
This review suggests that FDG-PET offers superior prognostic accuracy over SPECT and structural MRI in patients with mild cognitive impairment.
Limits
The abstract does not provide exact numerical effect sizes, confidence intervals, or total participant sample sizes. Specific prognostic definitions, clinical conversion endpoints, and follow-up lengths are also not detailed in the abstract.
Cited by
- contradicts Low blood flow is the number one brain imaging predictor of Alzheimer's disease.