Adipose Tissue Dysfunction and Obesity-Related Male Hypogonadism.
Level 5 - mechanism / opinion, no new human data
Narrative review focusing on biological mechanisms without systematic search methodology or new human data.
PubMed 35897769 · doi:10.3390/ijms23158194
What was done
This narrative review synthesized the proposed biological pathways linking obesity, adipose tissue dysfunction, and male hypogonadism, alongside current therapeutic options to address the condition.
What was found
The abstract outlines qualitative mechanistic pathways without providing quantitative figures. Adipose tissue dysfunction impairs the hypothalamic-pituitary-gonadal axis through increased aromatase-mediated conversion of testosterone to estradiol, elevated reactive oxygen species (ROS) production, and altered endocrine signaling. Additionally, androgen deficiency promotes adipose tissue expansion, exacerbating obesity and establishing a bidirectional vicious cycle. No numerical outcomes are reported.
Why it matters
It conceptualizes obesity-related male hypogonadism as a self-reinforcing endocrine loop driven by adipose tissue dysfunction and metabolic derangements.
Limits
The paper is a narrative overview without systematic search criteria, quality appraisal, or original empirical data. No sample sizes, quantitative estimates, or comparative treatment effect sizes are provided in the abstract.
Cited by
- supports Adipose tissue converts testosterone into forms of estrogen.