Benjamin Levine
Dr. Benjamin Levine is a medical researcher in the fields of cardiology and exercise physiology. His work investigates the cardiovascular impacts of aging and exercise, including methods to address cardiac stiffness and the hemodynamics of heart failure with preserved ejection fraction. His published research also covers sports cardiology, autonomic conditions such as postural orthostatic tachycardia syndrome, and physiological responses to altitude and hypoxia.
72 claims checked on air: 7 context 5 contradicted 2 overstated 50 supported 8 unverified
What they said on air - unverified
3 citing their own research
Following three weeks of bed rest, unfit participants returned to baseline fitness and exceeded it within 2 months of training, whereas fit athletes required the full 2 months and did not fully reach baseline.
"what was really interesting is that the three guys who were relatively unfit quickly returned to baseline and even got fitter than they were beforehand. For the fitter people, it took them the full 2 months to get back, and even then they weren't quite back at where they were." (said at 0:05:39)
No published record matching the claim that three unfit participants quickly returned to baseline and exceeded it within 2 months of training while fitter participants required the full 2 months and did not fully reach baseline was located; this does not prove the claim false.
The human heart begins to atrophy and shrink predominantly during late middle age, between the ages of 50 and 65.
"what we found is that the heart starts to shrink in that late middle-aged period. You know, if you think about aging, so late middle age is kind of that 50 to 65 period... it's in that late middle range that it starts to atrophy" (said at 0:18:50)
No published record matching the claim that the human heart begins to atrophy and shrink predominantly during late middle age (between the ages of 50 and 65) was located; this does not prove the claim false.
Exercise training increases vagal tone and parasympathetic neural activity even when initiated in one's 70s.
"So the ability to increase vagal tone or neural activity in that parasympathetic nerve may be very, very protective against sudden cardiac death, and those things will happen even if you start training in your 70s." (said at 0:31:48)
No published record matching the claim that exercise training increases vagal tone and parasympathetic neural activity when initiated in one's 70s was located; this does not prove the claim false.
The maximal heart rate achieved by elite endurance athletes during maximal exercise is equal to or lower than that of sedentary individuals.
"And the heart rate, the max heart rate of an elite athlete, if anything, is lower than that of a sedentary person." (said at 0:48:16)
No published record matching the specific comparative data on maximal heart rate between elite endurance athletes and sedentary individuals was located; this does not prove the claim false.
Carsten Lundby's group in Copenhagen demonstrated that when the exercise training dose is increased for individuals who appear to be non-responders, all of them improve cardiorespiratory fitness.
"And so Carsten Lundby and his group in Copenhagen has shown very clearly that if you take someone who's a non-responder—"non-responder" in quotes—and increase their training dose, they all improve." (said at 1:02:43)
No published record matching the claim that Carsten Lundby's group demonstrated that increasing exercise training dose eliminates non-responsiveness in cardiorespiratory fitness was located; this does not prove the claim false.
Adding intense arm exercise during intense leg exercise causes blood vessels in the legs to constrict because arterial blood pressure cannot be sustained if all exercising vascular beds are fully dilated, even at maximal cardiac output.
"let's call it the Saltin hypothesis about the cardiovascular limitation to exercise, because if you add arm exercise while you're doing intense leg exercise, you start to constrict the blood vessels even in the legs, because you simply cannot sustain your blood pressure with all the blood vessels relaxed, even with a maximal cardiac output." (said at 1:31:47)
No published record matching the claim that adding intense arm exercise to leg exercise causes vasoconstriction in the legs to maintain arterial blood pressure at maximal cardiac output was located; this does not prove the claim false.
Aaron Baggish's Run Across America study found an increase in coronary plaque in runners following the event.
"Aaron Baggish showed in Run Across America that when they did that, they had an increase in plaque." (said at 2:12:05)
No published record matching Aaron Baggish's involvement in a "Run Across America" study demonstrating an increase in coronary plaque following the event was located; this does not prove the claim false.
A Cooper Clinic analysis found that increasing exercise intensity is associated with lower coronary calcium, whereas increasing exercise duration is associated with higher coronary calcium.
"we have a new paper from the Cooper Clinic showing that if you try to parse out the exercise dose into intensity versus duration, as you increase the intensity, calcium is less, and as you increase duration, calcium goes up." (said at 2:12:15)
No published record matching the claim that a Cooper Clinic analysis found increasing exercise intensity is associated with lower coronary artery calcium while increasing duration is associated with higher coronary artery calcium was located; this does not prove the claim false. Published analyses from the Cooper Center Longitudinal Study have evaluated cardiorespiratory fitness, total physical activity volume, and coronary artery calcification, but have not reported an analysis demonstrating opposite directional associations for exercise intensity versus duration on coronary calcium.
Fact-checked episodes
Publications
- Circumferential strain and strain rates of the descending aorta as novel measures of aortic stiffness and wall mechanics from standard cardiac MRI.Experimental physiology 2026 · CEBM Level 4
- Healthy Aging at Moderate Altitudes.Gerontology 2026 · CEBM Level 5
- The Physiological and Altitude Lowering Effects of Different Supplemental Oxygen Flow Rates at Extreme Simulated Altitude: A Pilot Study.High altitude medicine & biology 2026 · CEBM Level 3
- Rationale and design of MUSIC-HFpEF: a phase 1b, pilot trial evaluating the safety and pharmacodynamic effects of AAV1.SERCA2A in heart failure with preserved ejection fraction.Heart failure reviews 2026 · CEBM Level 5
- Ventilatory limitation to exercise in patients with HFpEF and obesity: No room to breathe.Respiratory physiology & neurobiology 2026 · CEBM Level 3
- Opposing Legislative Mandates for ECG Screening in Competitive Athletes: A Report of the American College of Cardiology Solution Set Oversight Committee.Journal of the American College of Cardiology 2026 · CEBM Level 5
- Response by Berry et al to Letter Regarding Article, "High-Volume Physical Activity and Clinical Coronary Artery Disease Outcomes: Findings From the Cooper Center Longitudinal Study".Circulation 2026 · CEBM Level 5
- The effect of sex on ventricular filling pressure during graded exercise in healthy young adults.Journal of applied physiology (Bethesda, Md. : 1985) 2026 · CEBM Level 4
- Test-retest reliability of clinical supine-to-stand tests in patients with postural orthostatic tachycardia syndrome: A cautionary tale.Heart rhythm 2026 · CEBM Level 4
- Loss of Consciousness During Intense Exercise: Is It Hypotension or Not?JACC. Case reports 2026 · CEBM Level 4
- Resuscitated Cardiac Arrest From Cardiac Sarcoidosis in a Professional Basketball Player: A Slam Dunk Diagnosis?JACC. Case reports 2026 · CEBM Level 4
- Adolescent Athlete Returns to Competitive Basketball After Cardiac Arrest and Diagnosis of Probable Hypertrophic Cardiomyopathy.JACC. Case reports 2026 · CEBM Level 4
- Effects of Left Atrial Filling Pressure on Exercise Pulmonary Gas Exchange in HFpEF: Does the V-Wave Matter?Circulation. Heart failure 2026 · CEBM Level 5
- Fat Distribution and Postural Changes in Pulmonary Capillary Wedge Pressure in Patients With Obesity and Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure 2026 · CEBM Level 4
- Exercise in acute and subacute hypoxic conditions: physiological responses affecting oxygen delivery and their applications to human health.The Journal of physiology 2026 · CEBM Level 5
- Sex differences in the peripheral determinants of oxygen transport and utilization in patients with heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology 2026 · CEBM Level 4
- Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults.The Journal of physiology 2026 · CEBM Level 3
- Sports and Exercise Cardiology: A New Frontier in Cardiovascular Disease Management.Circulation. Population health and outcomes 2026 · CEBM Level 5
- Altitude-Associated Hemodynamic Alterations: Analysis from the Veterans Affairs Clinical Assessment, Reporting, and Tracking.Annals of the American Thoracic Society 2026 · CEBM Level 3
- Autonomic Dysfunction in Long COVID Is Distinct From Pure Autonomic Failure.Journal of the American College of Cardiology 2026 · CEBM Level 5
- Anxiety sensitivity in heart failure with preserved ejection fraction: Bias in dyspnea ratings and respiratory exercise response.Respiratory medicine 2026 · CEBM Level 4
- Oxygen cost of breathing and its association with dyspnea in older patients with heart failure with preserved ejection fraction and obesity.Journal of applied physiology (Bethesda, Md. : 1985) 2026 · CEBM Level 4
- Guidelines for rigor and reproducibility of heart rate variability within human cardiovascular research.American journal of physiology. Heart and circulatory physiology 2026 · CEBM Level 5
- Sex-specific association between obesity and sympathetic nerve activity in HFpEF.American journal of physiology. Heart and circulatory physiology 2026 · CEBM Level 4
- Plasticity of the heart in response to changes in physical activity.The Journal of physiology 2025 · CEBM Level 5
- Pulmonary gas exchange in relation to exercise pulmonary hypertension in patients with heart failure with preserved ejection fraction.The European respiratory journal 2025 · CEBM Level 3
- Heart Failure in Zero Gravity-External Constraint and Cardiac Hemodynamics.JAMA cardiology 2025 · CEBM Level 4
- Physiological Principles of Exercise.NEJM evidence 2025 · CEBM Level 5
- Clinical Conundrum: Climbing at the Extremes of High Elevation with Nonischemic Cardiomyopathy.High altitude medicine & biology 2025 · CEBM Level 4
- Coronary atherosclerosis in athletes: emerging concepts and preventive strategies.European heart journal 2025 · CEBM Level 5
- Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest.Experimental physiology 2025 · CEBM Level 3
- Cardiopulmonary Exercise Testing.NEJM evidence 2025 · CEBM Level 5
- Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology.Circulation 2025 · CEBM Level 5
- Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology.Journal of the American College of Cardiology 2025 · CEBM Level 5
- Effects of Year Long Aerobic Exercise on Left Atrial Size in Patients With Left Ventricular Hypertrophy.The American journal of cardiology 2025 · CEBM Level 2
- Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2025 · CEBM Level 4
- Insights Into the Role of Obesity in Heart Failure With Preserved Ejection Fraction: Pathophysiology and Management.The Canadian journal of cardiology 2025 · CEBM Level 5
- Correction to: Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology.Circulation 2025 · CEBM Level 5
- The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechanisms of exercise intolerance and dyspnea following pediatric pulmonary embolism.Research and practice in thrombosis and haemostasis 2025 · CEBM Level 5
- The Cardiovascular Care of the Pediatric Athlete.Journal of the American College of Cardiology 2025 · CEBM Level 5
- Recommendations for cardiac screening and emergency action planning in youth football: a FIFA consensus statement.British journal of sports medicine 2025 · CEBM Level 5
- "Predicting" fitness - does the heart measure up?European journal of preventive cardiology 2025 · CEBM Level 5
- High-Volume Physical Activity and Clinical Coronary Artery Disease Outcomes: Findings From the Cooper Center Longitudinal Study.Circulation 2025 · CEBM Level 3
- The Impact of Moderate Altitude on Manifestations of Coronary Artery Disease.Gerontology 2025 · CEBM Level 5
- Functional sympatholysis of neuropeptide Y-mediated vasoconstriction in humans.The Journal of physiology 2025 · CEBM Level 4
- Impaired exercise hemodynamic responses in patients with HFpEF without a sympathetic vasoconstrictor reserve.Autonomic neuroscience : basic & clinical 2025 · CEBM Level 4
- Heart-Lung Interactions in HFpEF: Dynamic Hyperinflation and Exercise PCWP.JACC. Heart failure 2025 · CEBM Level 4
- Exercise Intolerance and Response to Training in Patients With Postacute Sequelae of SARS-CoV2 (Long COVID): A Scientific Statement From the American Heart Association.Circulation 2025 · CEBM Level 5
- Xenon Inhalation for Expeditions to High Altitude: A Position Statement from the International Climbing and Mountaineering Federation (Union Internationale des Associations d'Alpinisme, UIAA) Medical Commission.High altitude medicine & biology 2025 · CEBM Level 5
- Exercise blood pressure in adults with high-risk left ventricular hypertrophy: the importance of normalizing blood pressure to oxygen uptake.Journal of hypertension 2025 · CEBM Level 4
- Exercise-induced arterial hypoxaemia in patients with heart failure with preserved ejection fraction.The Journal of physiology 2025 · CEBM Level 3
- Distinct blood volume and left ventricular adaptation to severe obesity in middle-aged adults at risk for heart failure.European journal of heart failure 2025 · CEBM Level 3
- Central and Peripheral Mechanisms of Low Exercise Capacity in Prematurely Born Adults.Comprehensive Physiology 2025 · CEBM Level 4
- Exacerbation of Postural Orthostatic Tachycardia Syndrome With Tirzepatide Prescribed for Weight Loss.JACC. Case reports 2025 · CEBM Level 4
- American College of Sports Medicine Expert Consensus Statement: Blood Doping in Sport.Medicine and science in sports and exercise 2025 · CEBM Level 5
- Cardiopulmonary Performance Among Heart Failure Patients Before and After Left Ventricular Assist Device Implantation.JACC. Heart failure 2024 · CEBM Level 3
- Cardiovascular remodelling in response to exercise training in patients after the Fontan procedure: a pilot study.Cardiology in the young 2024 · CEBM Level 4
- Attenuated peripheral oxygen extraction and greater cardiac output in women with posttraumatic stress disorder during exercise.Journal of applied physiology (Bethesda, Md. : 1985) 2024 · CEBM Level 4
- The Tactical Athlete: Definitions, Cardiovascular Assessment, and Management, and "Fit for Duty" Standards.Cardiac electrophysiology clinics 2024 · CEBM Level 5
- Potential for reducing resting sympathetic nerve activity with new classes of glucose-lowering drugs in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2024 · CEBM Level 5
- Sports Participation by Athletes With Cardiovascular Disease.Journal of the American College of Cardiology 2024 · CEBM Level 5
- Sympathetic Neural Control at Rest and During the Cold Pressor Test in Patients With Heart Failure With Preserved Ejection Fraction.Hypertension (Dallas, Tex. : 1979) 2024 · CEBM Level 4
- Right ventricular performance during acute hypoxic exercise.The Journal of physiology 2024 · CEBM Level 3
- The effect of chronic habitual exercise on oxygen carrying capacity and blood compartment volumes in older adults.Journal of applied physiology (Bethesda, Md. : 1985) 2024 · CEBM Level 4
- Respiratory symptom perception during exercise in patients with heart failure with preserved ejection fraction.Respiratory physiology & neurobiology 2024 · CEBM Level 4
- Coronary artery calcification and high-volume physical activity: role of lower intensity vs. longer duration of exercise.European journal of preventive cardiology 2024 · CEBM Level 4
- Unraveling the Unsolved Mysteries of the Athletic Heart.Circulation 2024 · CEBM Level 5
- Physical Activity and Progression of Coronary Artery Calcification in Men and Women.JAMA cardiology 2024 · CEBM Level 3
- Impaired longitudinal systolic-diastolic coupling and cardiac response to exercise in patients with hypertrophic cardiomyopathy.Echocardiography (Mount Kisco, N.Y.) 2024 · CEBM Level 4
- Racial Disparities in Sports Cardiology: A Review.JAMA cardiology 2024 · CEBM Level 5
- Identifying the Mechanisms of a Peripherally Limited Exercise Phenotype in Patients With Heart Failure With Preserved Ejection Fraction.Circulation. Heart failure 2024 · CEBM Level 3
- Cardiovascular Care of Tactical Athletes: Have We Landed Yet?JACC. Advances 2024 · CEBM Level 5
- All That Is Gold Does Not Glitter.Circulation 2024 · CEBM Level 5
- A contemporary review of sudden cardiac arrest and death in competitive and recreational athletes.Lancet (London, England) 2024 · CEBM Level 5
- Hypoxia and Cardiac Function in Patients With Prior Myocardial Infarction.Circulation research 2023 · CEBM Level 4
- Reducing Pulmonary Capillary Wedge Pressure During Exercise Exacerbates Exertional Dyspnea in Patients With Heart Failure With Preserved Ejection Fraction: Implications for V˙/Q˙ Mismatch.Chest 2023 · CEBM Level 2
- SERCA2a Agonist Effects on Cardiac Performance During Exercise in Heart Failure With Preserved Ejection Fraction.JACC. Heart failure 2023 · CEBM Level 2
- "Living High-Training Low" for Olympic Medal Performance: What Have We Learned 25 Years After Implementation?International journal of sports physiology and performance 2023 · CEBM Level 5
- Rationale and Design of the ORCCA (Outcomes Registry for Cardiac Conditions in Athletes) Study.Journal of the American Heart Association 2023 · CEBM Level 5
- Right Ventricular Response to Acute Hypoxia among Healthy Humans.American journal of respiratory and critical care medicine 2023 · CEBM Level 4
- Characterizing regional and global effects of epicardial adipose tissue on cardiac systolic and diastolic function.Obesity (Silver Spring, Md.) 2023 · CEBM Level 3
- Response by Sarma and Levine to Letters Regarding Article, "Challenging the Hemodynamic Hypothesis in Heart Failure With Preserved Ejection Fraction: Is Exercise Capacity Limited by Elevated Pulmonary Capillary Wedge Pressure?".Circulation 2023 · CEBM Level 5
- Cardiac Effects of Long-Duration Space Flight.Journal of the American College of Cardiology 2023 · CEBM Level 3
- Impact of Sex on Cardiovascular Adaptations to Exercise: JACC Review Topic of the Week.Journal of the American College of Cardiology 2023 · CEBM Level 5
- Ventilatory limitations in patients with HFpEF and obesity.Respiratory physiology & neurobiology 2023 · CEBM Level 4
- The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine.Medicine and science in sports and exercise 2023 · CEBM Level 5
- Assessment of venous pressure by compression sonography of the internal jugular vein during 3 days of bed rest.Experimental physiology 2023 · CEBM Level 3
- Effects of Synchronizing Foot Strike and Cardiac Phase on Exercise Hemodynamics in Patients With Cardiac Resynchronization Therapy: A Within-Subjects Pilot Study to Fine-Tune Cardio-Locomotor Coupling for Heart Failure.Circulation 2023 · CEBM Level 2
- Randomized Controlled Trial of Moderate- and High-Intensity Exercise Training in Patients With Hypertrophic Cardiomyopathy: Effects on Fitness and Cardiovascular Response to Exercise.Journal of the American Heart Association 2023 · CEBM Level 2
- Electrocardiographic changes during sustained normobaric hypoxia in patients after myocardial infarction.Scientific reports 2023 · CEBM Level 4
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) 2023 · CEBM Level 5
- Excess Pericardial Fat Is Related to Adverse Cardio-Mechanical Interaction in Heart Failure With Preserved Ejection Fraction.Circulation 2023 · CEBM Level 4