Chris McGlory
Queen's University
Chris McGlory is an assistant professor at Queen's University in Kingston, Ontario, Canada, specializing in muscle physiology and aging. His research investigates the molecular mechanisms governing muscle protein synthesis, proteostasis, and skeletal muscle adaptation to resistance exercise. Additionally, his published work examines the physiological effects of omega-3 fatty acid supplementation, muscle disuse, and sex-based differences in mitochondrial and exercise responses.
45 claims checked on air: 1 overstated 43 supported 1 unverified
What they said on air - overstated
7 citing their own research
Meta-analyses support that omega-3 supplementation improves muscle mass in humans.
"There are a couple of papers that have shown, you know, if you feed omega-3s, that improves muscle mass. There's meta-analyses supporting this" (said at 0:39:01)
While at least one meta-analysis of randomized trials in older adults reported a modest increase in muscle mass (weighted mean gain of ~0.33 kg, increasing to ~0.67 kg at doses >2 g/day), the majority of subsequent meta-analyses across healthy adults and older populations have found that omega-3 supplementation does not produce statistically significant gains in muscle or lean body mass. Some meta-analyses do, however, report small positive effects on muscle strength or physical performance measures.
- supports: Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance amon… (Nutrients 2020) · cited 134x in the literature
"There were minor benefits for muscle mass gain (0.33 kg; 95% CI: 0.05, 0.62) and timed up and go performance (-0.30 s; 95% CI: -0.43, -0.17). Subgroup analyses regarding muscle mass and walk speed indicated that omega-3 fatty acid supplements at more than 2 g/day may contribute to muscle mass gain (0.67 kg; 95% CI: 0.16, 1.18)" (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: Supplementation with omega-3 and lean body mass in the general population: A systematic re… (Clinical nutrition ESPEN 2021) · cited 10x in the literature
"In total, 11 studies were included, from which two found significant effects on lean body mass. In the meta-analysis, none of the results were significant. Omega-3 supplementation had no significant effect on lean body mass compared to placebo." (abstract, results and conclusions, passage verified)
pubmedfull study (doi) - contradicts: Effects of Omega-3 Supplementation Alone and Combined with Resistance Exercise on Skeletal… (Nutrients 2022) · cited 76x in the literature
"ω-3 fatty acid supplementation did not impact lean tissue mass (SMD 0.09 [-0.10, 0.28]). Benefits were observed for lower body strength (SMD 0.54 [0.33, 0.75]), timed-up-and-go (MD 0.29 [0.23, 0.35]s), and 30-s sit-to-stand performance" (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: The Influence of n-3PUFA Supplementation on Muscle Strength, Mass, and Function: A Systema… (Advances in nutrition (Bethesda, Md.) 2023) · cited 26x in the literature
"n-3PUFA supplementation had no significant effect on muscle mass (standard mean difference [SMD] = 0.07 [95% CI: -0.02, 0.17], P = 0.11) and muscle function (SMD = 0.03 [95% CI: -0.09, 0.15], P = 0.58), but it showed a very small albeit significant positive effect on muscle strength (SMD = 0.12 [95% CI: 0.006, 0.24], P = 0.04) in participants when compared with placebo." (abstract, results, passage verified)
pubmedfull study (doi)
Fact-checked episodes
Publications
- Omega-3 fatty acid supplementation does not attenuate declines in skeletal muscle mitochondrial area in young, healthy females during immobilization.Physiological reports 2026 · CEBM Level 2
- Acute and Chronic High-Intensity Exercise Differentially Regulate the miRNA Biogenesis Pathway in Human Skeletal Muscle.Genes 2026 · CEBM Level 3
- Physiological and perceptual response to critical power anchored HIIT: a sex comparison study.European journal of applied physiology 2025 · CEBM Level 3
- Plantar flexor strength and size decrease following single-leg disuse in uninjured adults: A meta-analysis.Clinical physiology and functional imaging 2025 · CEBM Level 2
- Deuterated water ( 2 H 2 O) can be used to quantify hemoglobin synthesis and red blood cell lifespan in humans.Acta physiologica (Oxford, England) 2025 · CEBM Level 4
- Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?Experimental physiology 2025 · CEBM Level 5
- Biological sex does not impact intrinsic mitochondrial respiration supported by complexes I and II in human skeletal muscle.Experimental physiology 2025 · CEBM Level 4
- Hemoglobin synthesis rates in young trained and untrained males and females are not different.Physiological reports 2025 · CEBM Level 3
- Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth.Nature metabolism 2025 · CEBM Level 5
- The influence of biological sex on skeletal muscle phospholipid membrane composition in response to omega n-3 polyunsaturated fatty acid supplementation and washout in humans.Prostaglandins, leukotrienes, and essential fatty acids 2025 · CEBM Level 3
- Advancing Geroscience Research - A Scoping Review of Regulatory Environments for Gerotherapeutics.The journal of nutrition, health & aging 2025 · CEBM Level 5
- The impact of menstrual phase on lower limb microvascular function, ERα, eNOS, and p-eNOS protein in premenopausal females.Journal of applied physiology (Bethesda, Md. : 1985) 2025 · CEBM Level 3
- Editorial.Current opinion in clinical nutrition and metabolic care 2025 · CEBM Level 5
- Platelet bioenergetics correlate with skeletal muscle respiration in a murine model of type II diabetes.Frontiers in molecular biosciences 2025 · CEBM Level 5
- Resistance training load does not determine resistance training-induced hypertrophy across upper and lower limbs in healthy young males.The Journal of physiology 2025 · CEBM Level 2
- Does Aerobic Exercise Increase Skeletal Muscle Mass in Female and Male Adults?Medicine and science in sports and exercise 2024 · CEBM Level 2
- Low baseline ribosome-related gene expression and resistance training-induced declines in ribosome-related gene expression are associated with skeletal muscle hypertrophy in young men and women.Journal of cellular physiology 2024 · CEBM Level 3
- Does perceived caloric and nutrient intake influence the acute effect of beverage consumption on cardiovascular function?Journal of applied physiology (Bethesda, Md. : 1985) 2024 · CEBM Level 2
- Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.bioRxiv : the preprint server for biology 2024 · CEBM Level 3
- The Effect of Multi-Ingredient Protein versus Collagen Supplementation on Satellite Cell Properties in Males and Females.Medicine and science in sports and exercise 2024 · CEBM Level 2
- Nutritional intervention to enhance recovery after arthroscopic knee surgery in adults: a randomized controlled pilot trial.Pilot and feasibility studies 2024 · CEBM Level 5
- Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth.Research square 2024 · CEBM Level 5
- Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.NAR molecular medicine 2024 · CEBM Level 3
- Impact of exercise and fasting on mitochondrial regulators in human muscle.Translational exercise biomedicine 2024 · CEBM Level 3
- Does initial skeletal muscle size or sex affect the magnitude of muscle loss in response to 14 days immobilization?Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2023 · CEBM Level 3
- Single-leg disuse decreases skeletal muscle strength, size, and power in uninjured adults: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle 2023 · CEBM Level 1
- The effects of single-leg disuse on skeletal muscle strength and size in the nonimmobilized leg of uninjured adults: a meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) 2023 · CEBM Level 1
- Lipidomic studies reveal two specific circulating phosphatidylcholines as surrogate biomarkers of the omega-3 index.Journal of lipid research 2023 · CEBM Level 2
- Dairy and Dairy Alternative Supplementation Increase Integrated Myofibrillar Protein Synthesis Rates, and Are Further Increased when Combined with Walking in Healthy Older Women.The Journal of nutrition 2022 · CEBM Level 2
- Sex-Based Differences in the Myogenic Response and Inflammatory Gene Expression Following Eccentric Contractions in Humans.Frontiers in physiology 2022 · CEBM Level 3
- Declines in muscle protein synthesis account for short-term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown.Journal of cachexia, sarcopenia and muscle 2022 · CEBM Level 3
- Short-term aerobic conditioning prior to resistance training augments muscle hypertrophy and satellite cell content in healthy young men and women.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 · CEBM Level 3
- Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 · CEBM Level 2
- Aerobic conditioning alters the satellite cell and ribosome response to acute eccentric contractions in young men and women.American journal of physiology. Cell physiology 2022 · CEBM Level 3
- Omega-3 fatty acids and human skeletal muscle.Current opinion in clinical nutrition and metabolic care 2021 · CEBM Level 5
- Both Traditional and Stair Climbing-based HIIT Cardiac Rehabilitation Induce Beneficial Muscle Adaptations.Medicine and science in sports and exercise 2021 · CEBM Level 2
- Methodological considerations for and validation of the ultrasonographic determination of human skeletal muscle hypertrophy and atrophy.Physiological reports 2021 · CEBM Level 3
- Two weeks of single-leg immobilization alters intramyocellular lipid storage characteristics in healthy, young women.Journal of applied physiology (Bethesda, Md. : 1985) 2021 · CEBM Level 2
- Brief Vigorous Stair Climbing Effectively Improves Cardiorespiratory Fitness in Patients With Coronary Artery Disease: A Randomized Trial.Frontiers in sports and active living 2021 · CEBM Level 2
- The Effect of a Multi-ingredient Supplement on Resistance Training-induced Adaptations.Medicine and science in sports and exercise 2021 · CEBM Level 2
- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 · CEBM Level 3
- Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 · CEBM Level 3
- Fish Oil for Healthy Aging: Potential Application to Master Athletes.Sports medicine (Auckland, N.Z.) 2021 · CEBM Level 5
- Lactalbumin, Not Collagen, Augments Muscle Protein Synthesis with Aerobic Exercise.Medicine and science in sports and exercise 2020 · CEBM Level 2
- Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial.The American journal of clinical nutrition 2020 · CEBM Level 2
- Correction to: Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes.Diabetologia 2020 · CEBM Level 5
- Serum nonesterified fatty acids have utility as dietary biomarkers of fat intake from fish, fish oil, and dairy in women.Journal of lipid research 2020 · CEBM Level 3
- Potato Protein Isolate Stimulates Muscle Protein Synthesis at Rest and with Resistance Exercise in Young Women.Nutrients 2020 · CEBM Level 2
- Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States.Cell reports 2020 · CEBM Level 2
- Human skeletal muscle metabolic responses to 6 days of high-fat overfeeding are associated with dietary n-3PUFA content and muscle oxidative capacity.Physiological reports 2020 · CEBM Level 2
- The impact of exercise and nutrition on the regulation of skeletal muscle mass.The Journal of physiology 2019 · CEBM Level 5
- Aminoacidemia following ingestion of native whey protein, micellar casein, and a whey-casein blend in young men.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2019 · CEBM Level 2
- Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men.Medicine and science in sports and exercise 2019 · CEBM Level 2
- Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 · CEBM Level 2
- Maintenance of skeletal muscle function following reduced daily physical activity in healthy older adults: a pilot trial.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2019 · CEBM Level 3
- Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 · CEBM Level 2
- Metabolic Perturbations from Step Reduction in Older Persons at Risk for Sarcopenia: Plasma Biomarkers of Abrupt Changes in Physical Activity.Metabolites 2019 · CEBM Level 3
- Muscle fibre activation is unaffected by load and repetition duration when resistance exercise is performed to task failure.The Journal of physiology 2019 · CEBM Level 2
- A Novel Amino Acid Composition Ameliorates Short-Term Muscle Disuse Atrophy in Healthy Young Men.Frontiers in nutrition 2019 · CEBM Level 2
- Consistent expression pattern of myogenic regulatory factors in whole muscle and isolated human muscle satellite cells after eccentric contractions in humans.Journal of applied physiology (Bethesda, Md. : 1985) 2019 · CEBM Level 4
- The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease.Frontiers in nutrition 2019 · CEBM Level 5
- The effect of oral essential amino acids on incretin hormone production in youth and ageing.Endocrinology, diabetes & metabolism 2019 · CEBM Level 3
- Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 · CEBM Level 2
- Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences 2018 · CEBM Level 3
- Recent Perspectives Regarding the Role of Dietary Protein for the Promotion of Muscle Hypertrophy with Resistance Exercise Training.Nutrients 2018 · CEBM Level 5
- Sex differences in mitochondrial respiratory function in human skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology 2018 · CEBM Level 4
- Assessing the mechanistic target of rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2018 · CEBM Level 3
- Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes.Diabetologia 2018 · CEBM Level 4
- Leucine, Not Total Protein, Content of a Supplement Is the Primary Determinant of Muscle Protein Anabolic Responses in Healthy Older Women.The Journal of nutrition 2018 · CEBM Level 2
- Resistance training in young men induces muscle transcriptome-wide changes associated with muscle structure and metabolism refining the response to exercise-induced stress.European journal of applied physiology 2018 · CEBM Level 3
- A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein synthesis during inactivity and energy restriction in older persons.The American journal of clinical nutrition 2018 · CEBM Level 2
- Skeletal muscle and resistance exercise training; the role of protein synthesis in recovery and remodeling.Journal of applied physiology (Bethesda, Md. : 1985) 2017 · CEBM Level 5
- Investigating human skeletal muscle physiology with unilateral exercise models: when one limb is more powerful than two.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2017 · CEBM Level 5
- Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise.American journal of physiology. Cell physiology 2017 · CEBM Level 3
- Growing older with health and vitality: a nexus of physical activity, exercise and nutrition.Biogerontology 2016 · CEBM Level 5
- Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men.Physiological reports 2016 · CEBM Level 2
- Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men.Journal of applied physiology (Bethesda, Md. : 1985) 2016 · CEBM Level 2
- The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein.Physiological reports 2016 · CEBM Level 2
- Green tea extract does not affect exogenous glucose appearance but reduces insulinemia with glucose ingestion in exercise recovery.Journal of applied physiology (Bethesda, Md. : 1985) 2016 · CEBM Level 2
- Leucine supplementation enhances integrative myofibrillar protein synthesis in free-living older men consuming lower- and higher-protein diets: a parallel-group crossover study.The American journal of clinical nutrition 2016 · CEBM Level 2
- Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy.Frontiers in physiology 2015 · CEBM Level 5
- Exercise and the Regulation of Skeletal Muscle Hypertrophy.Progress in molecular biology and translational science 2015 · CEBM Level 5
- Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) 2014 · CEBM Level 5
- Temporal changes in human skeletal muscle and blood lipid composition with fish oil supplementation.Prostaglandins, leukotrienes, and essential fatty acids 2014 · CEBM Level 4
- Assessing the regulation of skeletal muscle plasticity in response to protein ingestion and resistance exercise: recent developments.Current opinion in clinical nutrition and metabolic care 2014 · CEBM Level 5
- CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis.The Journal of physiology 2014 · CEBM Level 5
- Rebuttal from Stuart M. Phillips and Chris McGlory.The Journal of physiology 2014 · CEBM Level 5
- Pattern of protein ingestion to maximise muscle protein synthesis after resistance exercise.The Journal of physiology 2013 · CEBM Level 5
- N-Acetylcysteine's attenuation of fatigue after repeated bouts of intermittent exercise: practical implications for tournament situations.International journal of sport nutrition and exercise metabolism 2011 · CEBM Level 2
- The effects of postexercise consumption of high-molecular-weight versus low-molecular-weight carbohydrate solutions on subsequent high-intensity interval-running capacity.International journal of sport nutrition and exercise metabolism 2010 · CEBM Level 2