Dale Bredesen
Dale Bredesen is a researcher whose work focuses on cognitive decline and Alzheimer's disease. His published research investigates precision medicine and multi-factorial interventions, including dietary protocols such as the KetoFLEX 12/3 diet and personalized therapeutic programs. Additionally, his studies explore molecular mechanisms, metabolic pathways, and targeted pharmacological agents for Alzheimer's disease.
31 claims checked on air: 3 context 1 contradicted 4 overstated 19 supported 4 unverified
What they said on air - contradicted
2 citing their own research
A study found an association between high levels of Akkermansia muciniphila in the gut and amyotrophic lateral sclerosis (ALS).
"There was one study that suggested that high Akkermansia was associated with ALS." (said at 0:47:15)
Published evidence on the gut microbiome in amyotrophic lateral sclerosis (ALS) demonstrates the inverse relationship: Akkermansia muciniphila is depleted in patients with ALS and has been shown to be protective, not associated with disease promotion or elevated levels. A landmark 2019 study in Nature showed that Akkermansia muciniphila ameliorated ALS symptoms and extended survival in transgenic ALS mouse models via nicotinamide production, while human ALS cohorts exhibited reduced abundance of beneficial commensals like Akkermansia. Although elevated Akkermansia has been reported in other neurodegenerative conditions (such as Parkinson's disease and multiple sclerosis), published ALS studies identify low, not high, Akkermansia abundance.
Fact-checked episodes
Publications
- KetoFLEX 12/3 Diet and Cognitive Health: A Precision-Nutrition Perspective on Mechanisms, Emerging Evidence, and Future Directions.Nutrients 2026 · CEBM Level 5
- Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer's disease.Scientific reports 2025 · CEBM Level 5
- Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 · CEBM Level 5
- Multidomain therapy for Alzheimer's disease: a scoping review of cognitive decline trials.Molecular neurodegeneration 2025 · CEBM Level 5
- Short-Term Changes in Depressive Symptoms Among Patients with Alzheimer's Disease Following a Precision Medicine Intervention.Brain sciences 2025 · CEBM Level 4
- Sustained Cognitive Improvement in Alzheimer's Disease Patients Following a Precision Medicine Protocol: Case Series.Biomedicines 2024 · CEBM Level 4
- Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review.International journal of molecular sciences 2023 · CEBM Level 5
- Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?The American journal of clinical nutrition 2023 · CEBM Level 5
- Precision Medicine Approach to Alzheimer's Disease: Rationale and Implications.Journal of Alzheimer's disease : JAD 2023 · CEBM Level 5
- Longitudinal White and Gray Matter Response to Precision Medicine-Guided Intervention for Alzheimer's Disease.Journal of Alzheimer's disease : JAD 2023 · CEBM Level 4
- Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.Journal of Alzheimer's disease : JAD 2022 · CEBM Level 4
- Neuroprotective Herbs for the Management of Alzheimer's Disease.Biomolecules 2021 · CEBM Level 5
- ReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline.Biomedicines 2021 · CEBM Level 4
- Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer's Disease.Journal of Alzheimer's disease & Parkinsonism 2021 · CEBM Level 4
- Alzheimer's disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics.Aging 2020 · CEBM Level 5
- Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease.Molecular neurobiology 2018 · CEBM Level 5
- A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.Scientific reports 2018 · CEBM Level 5
- Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 · CEBM Level 4
- Ayurvedic Profiling of Alzheimer's Disease.Alternative therapies in health and medicine 2017 · CEBM Level 5
- Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production.Frontiers in pharmacology 2017 · CEBM Level 5
- Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease.Molecular and cellular neurosciences 2017 · CEBM Level 5
- Direct Transcriptional Effects of Apolipoprotein E.The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 · CEBM Level 5
- Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic.Aging 2016 · CEBM Level 4
- Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD 2016 · CEBM Level 5
- Reversal of cognitive decline in Alzheimer's disease.Aging 2016 · CEBM Level 4
- Correction to hunter-killer peptide (HKP) for targeted therapy.Journal of medicinal chemistry 2015 · CEBM Level 5
- ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 · CEBM Level 4
- Dynamic self-guiding analysis of Alzheimer's disease.Oncotarget 2015 · CEBM Level 5
- Metabolic profiling distinguishes three subtypes of Alzheimer's disease.Aging 2015 · CEBM Level 4
- sAβPPα is a Potent Endogenous Inhibitor of BACE1.Journal of Alzheimer's disease : JAD 2015 · CEBM Level 5
- Alzheimer's Model Develops Early ADHD Syndrome.Journal of neurology & neurophysiology 2015 · CEBM Level 5
- The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.Brain research 2014 · CEBM Level 5
- Paradoxical effect of TrkA inhibition in Alzheimer's disease models.Journal of Alzheimer's disease : JAD 2014 · CEBM Level 5
- Reversal of cognitive decline: a novel therapeutic program.Aging 2014 · CEBM Level 4
- The small co-chaperone p23 overexpressing transgenic mouse.Journal of neuroscience methods 2013 · CEBM Level 5
- Next generation therapeutics for Alzheimer's disease.EMBO molecular medicine 2013 · CEBM Level 5
- AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease.Journal of Alzheimer's disease : JAD 2013 · CEBM Level 5
- Neuroprotective Sirtuin ratio reversed by ApoE4.Proceedings of the National Academy of Sciences of the United States of America 2013 · CEBM Level 5
- The small chaperone protein p23 and its cleaved product p19 in cellular stress.Journal of molecular neuroscience : MN 2012 · CEBM Level 5
- Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?Antioxidants & redox signaling 2012 · CEBM Level 5
- Ayurvedic medicinal plants for Alzheimer's disease: a review.Alzheimer's research & therapy 2012 · CEBM Level 5
- Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain.PloS one 2012 · CEBM Level 5
- Moonlighting peptides with emerging function.PloS one 2012 · CEBM Level 5
- No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 · CEBM Level 5
- mCiRNA-synaptic crystal ball?Aging 2012 · CEBM Level 5
- Signaling via amyloid precursor-like proteins APLP1 and APLP2.Journal of Alzheimer's disease : JAD 2011 · CEBM Level 5
- Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration.Journal of molecular neuroscience : MN 2011 · CEBM Level 5
- Dependence receptors: from basic research to drug development.Science signaling 2011 · CEBM Level 5
- Induction of the C-terminal proteolytic cleavage of AβPP by statins.Journal of Alzheimer's disease : JAD 2011 · CEBM Level 5
- Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides.Journal of Alzheimer's disease : JAD 2011 · CEBM Level 5
- Endogenously EGFP-Labeled Mouse Embryonic Stem Cells.Aging and disease 2011 · CEBM Level 5
- Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.PloS one 2011 · CEBM Level 5
- Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience.Behavioural brain research 2010 · CEBM Level 5
- In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP.Free radical biology & medicine 2010 · CEBM Level 5
- Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · CEBM Level 5
- Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.PloS one 2010 · CEBM Level 5
- Identification of new modulators and protein alterations in non-apoptotic programmed cell death.Journal of cellular biochemistry 2010 · CEBM Level 5
- Importance of the caspase cleavage site in amyloid-β protein precursor.Journal of Alzheimer's disease : JAD 2010 · CEBM Level 5
- Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.Journal of molecular neuroscience : MN 2009 · CEBM Level 5
- Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.Annals of neurology 2009 · CEBM Level 5
- Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence.Molecular neurodegeneration 2009 · CEBM Level 5
- Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.Biochemical and biophysical research communications 2009 · CEBM Level 5
- Novel mediators of amyloid precursor protein signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 · CEBM Level 5
- Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.Journal of neurochemistry 2008 · CEBM Level 5
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.Autophagy 2008 · CEBM Level 5
- C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease.Journal of Alzheimer's disease : JAD 2008 · CEBM Level 4
- Programmed cell death mechanisms in neurological disease.Current molecular medicine 2008 · CEBM Level 5
- Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.Behavioural brain research 2008 · CEBM Level 5
- Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin.Apoptosis : an international journal on programmed cell death 2008 · CEBM Level 5
- Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat.Neuromolecular medicine 2008 · CEBM Level 5
- Hunter-killer peptide (HKP) for targeted therapy.Journal of medicinal chemistry 2008 · CEBM Level 5
- An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.Journal of molecular recognition : JMR 2007 · CEBM Level 5
- Key note lecture: toward a mechanistic taxonomy for cell death programs.Stroke 2007 · CEBM Level 5
- A calpain-like protease inhibits autophagic cell death.Autophagy 2007 · CEBM Level 5
- Efficient identification of critical residues based only on protein structure by network analysis.PloS one 2007 · CEBM Level 5
- A novel motif identified in dependence receptors.PloS one 2007 · CEBM Level 5
- Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.The Journal of biological chemistry 2007 · CEBM Level 5
- Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex.Neurobiology of disease 2007 · CEBM Level 5
- The PDZ domain as a complex adaptive system.PloS one 2007 · CEBM Level 5
- Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation.Neuromolecular medicine 2007 · CEBM Level 5
- Neurogenesis in the adult brain: implications for Alzheimer's disease.CNS & neurological disorders drug targets 2007 · CEBM Level 5
- Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. 1985.Journal of neurosurgery 2007 · CEBM Level 4
- APP-based neuroprotective strategies.Current Alzheimer research 2007 · CEBM Level 5
- Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.Proceedings of the National Academy of Sciences of the United States of America 2006 · CEBM Level 5
- Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing.FEBS letters 2006 · CEBM Level 5
- Cell death in the nervous system.Nature 2006 · CEBM Level 5
- Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 · CEBM Level 5
- A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.Annals of neurology 2005 · CEBM Level 4
- Improved prediction of critical residues for protein function based on network and phylogenetic analyses.BMC bioinformatics 2005 · CEBM Level 5
- Developmental shift in the apostat: comparison of neurones and astrocytes.FEBS letters 2005 · CEBM Level 5
- Science fact and the SENS agenda. What can we reasonably expect from ageing research?EMBO reports 2005 · CEBM Level 5
- Molecular components of a cell death pathway activated by endoplasmic reticulum stress.The Journal of biological chemistry 2004 · CEBM Level 5
- siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme.Biochemical and biophysical research communications 2004 · CEBM Level 5
- Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.The Journal of biological chemistry 2004 · CEBM Level 5
- Target-assisted iterative screening of phage surface display cDNA libraries.Methods in molecular biology (Clifton, N.J.) 2004 · CEBM Level 5
- Apoptosis and dependence receptors: a molecular basis for cellular addiction.Physiological reviews 2004 · CEBM Level 5
- Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD.Journal of neurochemistry 2004 · CEBM Level 5
- Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.Proceedings of the National Academy of Sciences of the United States of America 2004 · CEBM Level 5
- Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.Nature 2004 · CEBM Level 5
- The non-existent aging program: how does it work?Aging cell 2004 · CEBM Level 5
- Rebuttal to Austad: 'Is aging programmed?Aging cell 2004 · CEBM Level 5
- Misfolded proteins, endoplasmic reticulum stress and neurodegeneration.Current opinion in cell biology 2004 · CEBM Level 5
- Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex.Neuromolecular medicine 2004 · CEBM Level 5
- Toward a mechanistic taxonomy of cell death programs.Journal of Alzheimer's disease : JAD 2004 · CEBM Level 5
- Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).The Journal of biological chemistry 2003 · CEBM Level 5
- An artificially designed pore-forming protein with anti-tumor effects.The Journal of biological chemistry 2003 · CEBM Level 5
- Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).Cytokine & growth factor reviews 2003 · CEBM Level 5
- Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening.The Journal of biological chemistry 2003 · CEBM Level 5
- Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice.Neurobiology of disease 2003 · CEBM Level 5
- Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity.Journal of neurochemistry 2003 · CEBM Level 5
- Meeting report: cellular dependence--old concept, new mechanisms.Science's STKE : signal transduction knowledge environment 2003 · CEBM Level 5
- Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes.Annals of neurology 2003 · CEBM Level 5
- Targeting the prostate for destruction through a vascular address.Proceedings of the National Academy of Sciences of the United States of America 2002 · CEBM Level 5
- Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway.The Journal of biological chemistry 2002 · CEBM Level 5
- Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78.FEBS letters 2002 · CEBM Level 5
- Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins.Journal of biomolecular structure & dynamics 2002 · CEBM Level 5
- PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor.Neuromolecular medicine 2002 · CEBM Level 5
- Caspase cleavage of members of the amyloid precursor family of proteins.Journal of neurochemistry 2002 · CEBM Level 5
- Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 · CEBM Level 5