Derya Unutmaz
Derya Unutmaz is a biomedical researcher working in immunology and computational biology. His published research focuses on CAR T-cell therapies for autoimmune diseases and cancer, single-cell mapping of the human immune system across the lifespan, and artificial intelligence-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). He has also investigated gut microbiome-host interactions, metabolomics, and immune responses in conditions such as long COVID.
35 claims checked on air: 4 context 2 contradicted 3 overstated 23 supported 3 unverified
What they said on air - unverified
A recent study published in Science found that the OpenAI o1 preview model performed significantly better than the average doctor in diagnosing medical conditions.
"Uh in fact, uh a Science paper came out recently, which was done with o1 preview model, which is a very old model... And um and they found that o1 model uh did did better than average doctor in diagnosing, like significantly better. They did didn't miss." (said at 0:44:05)
No published record matching a study in Science demonstrating that the OpenAI o1 preview model performed significantly better than the average doctor in diagnosing medical conditions was located; this does not prove the claim false.
An Australian computer scientist used AI models including ChatGPT to design an individualized mRNA vaccine that caused tumor regression in his dog diagnosed with melanoma.
"You probably heard of this story from Australia. This computer scientist um had ChatGPT and and some other AI models to develop an mRNA vaccine for his dog. His dog had I think a melanoma, and he um he got it sequenced. He took the sequence and gave it gave it to to an AI model, and the AI model designed the precise mRNA molecule that needs that the dog needs dog's immune system needs to be trained, got it synthesized, and I think it was able to apply it in 3 months. Um probably could have been shorter if there wasn't regulations, and and the tumor started to to regress, and the dog is was was alive when it was supposed to to die." (said at 1:07:38)
No published record matching the case of an Australian computer scientist using ChatGPT or other AI models to design a personalized mRNA vaccine that induced tumor regression in a dog with melanoma was located; this does not prove the claim false.
A machine learning study utilizing UK Biobank data from 500,000 participants was able to predict approximately 1,000 diseases before clinical onset.
"There was a study from um UK Biobank. Um UK has this amazing biobank with 500,000 people, uh lots of data sets, incredible data sets. And so and this was actually done I think more than a year ago with models that were a year or two years old. They took a lot of that data, and they were able to predict about thousand diseases before they happened." (said at 1:13:35)
No published record matching the claim that a machine learning model utilizing UK Biobank data predicted approximately 1,000 diseases before onset was located; this does not prove the claim false. While the UK Biobank includes approximately 500,000 participants and has been widely used to train machine learning and multi-omics models for incident disease prediction, published multi-disease prediction models typically evaluate dozens to a few hundred distinct conditions rather than approximately 1,000 individual diseases.
Fact-checked episodes
Publications
- Roads and detours for CAR T cell therapy in autoimmune diseases.Nature reviews. Drug discovery 2026 · CEBM Level 5
- Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury.BMJ open respiratory research 2026 · CEBM Level 5
- Editorial: Interdisciplinary innovations in CAR T-cell therapy for autoimmune and cancer treatment.Frontiers in immunology 2026 · CEBM Level 5
- Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.Nature communications 2026 · CEBM Level 4
- BioMapAI: Artificial Intelligence Multi-Omics Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.bioRxiv : the preprint server for biology 2025 · CEBM Level 3
- Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury.bioRxiv : the preprint server for biology 2025 · CEBM Level 5
- Novel Flavonoid Derivatives Show Potent Efficacy in Human Lymphoma Models.EJHaem 2025 · CEBM Level 5
- AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome.Nature medicine 2025 · CEBM Level 3
- Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.bioRxiv : the preprint server for biology 2025 · CEBM Level 4
- Bioassay-Driven, Fractionation-Empowered, Focused Metabolomics for Discovering Bacterial Activators of Aryl Hydrocarbon Receptor.Journal of the American Society for Mass Spectrometry 2024 · CEBM Level 5
- Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential.Frontiers in immunology 2024 · CEBM Level 5
- Fast Targeted Metabolomics for Analyzing Metabolic Diversity of Bacterial Indole Derivatives in ME/CFS Gut Microbiome.bioRxiv : the preprint server for biology 2024 · CEBM Level 4
- Multi-'omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients.Cell host & microbe 2023 · CEBM Level 4
- Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Work (Reading, Mass.) 2023 · CEBM Level 4
- A genome-wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs.Frontiers in molecular biosciences 2023 · CEBM Level 5
- GARP on hepatic stellate cells is essential for the development of liver fibrosis.Journal of hepatology 2023 · CEBM Level 5
- Cognitive impairment in post-acute sequelae of COVID-19 and short duration myalgic encephalomyelitis patients is mediated by orthostatic hemodynamic changes.Frontiers in neuroscience 2023 · CEBM Level 3
- STAT4 Phosphorylation of T-helper Cells predicts surgical outcomes in Refractory Chronic Rhinosinusitis.medRxiv : the preprint server for health sciences 2023 · CEBM Level 3
- Antibody Responses to SARS-CoV-2 After Infection or Vaccination in Children and Young Adults With Inflammatory Bowel Disease.Inflammatory bowel diseases 2022 · CEBM Level 3
- CCR5: The Receptor That Unlocks the Door for HIV Entry into Cells.Journal of immunology (Baltimore, Md. : 1950) 2022 · CEBM Level 5
- Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity.Cell systems 2022 · CEBM Level 4
- Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors.Biofabrication 2022 · CEBM Level 5
- Engineering Human MAIT Cells with Chimeric Antigen Receptors for Cancer Immunotherapy.Journal of immunology (Baltimore, Md. : 1950) 2022 · CEBM Level 5
- Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury.Oxidative medicine and cellular longevity 2022 · CEBM Level 5
- Targeting SARS-CoV-2 infection through CAR-T-like bispecific T cell engagers incorporating ACE2.Clinical & translational immunology 2022 · CEBM Level 5
- Improvement of Long COVID symptoms over one year.Frontiers in medicine 2022 · CEBM Level 3
- Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model.Advanced functional materials 2022 · CEBM Level 5
- Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis.Molecular biology of the cell 2021 · CEBM Level 5
- SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus.Communications biology 2021 · CEBM Level 4
- Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment.Advanced biology 2021 · CEBM Level 5
- Disease Progression in Children With Perinatal Human Immunodeficiency Virus Correlates With Increased PD-1+ CD8 T Cells That Coexpress Multiple Immune Checkpoints.The Journal of infectious diseases 2021 · CEBM Level 4
- 3D Bioprinting for fabrication of tissue models of COVID-19 infection.Essays in biochemistry 2021 · CEBM Level 5
- Antibody Responses to SARS-CoV-2 after Infection or Vaccination in Children and Young Adults with Inflammatory Bowel Disease.medRxiv : the preprint server for health sciences 2021 · CEBM Level 3
- Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19.Frontiers in aging 2021 · CEBM Level 5
- Decoy exosomes provide protection against bacterial toxins.Nature 2020 · CEBM Level 5
- Structure-based discovery of a small-molecule inhibitor of methicillin-resistant Staphylococcus aureus virulence.The Journal of biological chemistry 2020 · CEBM Level 5
- LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia.Molecular and cellular biology 2020 · CEBM Level 5
- A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T reg cells.Nature 2020 · CEBM Level 5
- STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.EMBO molecular medicine 2020 · CEBM Level 5
- Novel SARS-CoV-2 specific antibody and neutralization assays reveal wide range of humoral immune response during COVID-19.medRxiv : the preprint server for health sciences 2020 · CEBM Level 4
- 3D bioprinting for reconstituting the cancer microenvironment.NPJ precision oncology 2020 · CEBM Level 5
- Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients.Journal of translational medicine 2020 · CEBM Level 4
- Mechanisms of T-Cell Exhaustion in Pancreatic Cancer.Cancers 2020 · CEBM Level 5
- Immune cells for microbiota surveillance.Science (New York, N.Y.) 2019 · CEBM Level 5
- Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer.Breast cancer research and treatment 2018 · CEBM Level 3
- ORAI1 mutations abolishing store-operated Ca 2+ entry cause anhidrotic ectodermal dysplasia with immunodeficiency.The Journal of allergy and clinical immunology 2018 · CEBM Level 4
- Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing.Journal of immunology (Baltimore, Md. : 1950) 2018 · CEBM Level 5
- Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies.JCO precision oncology 2018 · CEBM Level 4
- Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation.Mucosal immunology 2018 · CEBM Level 5
- Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease.Frontiers in immunology 2018 · CEBM Level 4
- T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.Immunity 2018 · CEBM Level 5
- The role of platelet and endothelial GARP in thrombosis and hemostasis.PloS one 2017 · CEBM Level 5
- HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions.The Journal of infectious diseases 2017 · CEBM Level 4
- Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.Journal of immunology (Baltimore, Md. : 1950) 2016 · CEBM Level 5
- FOXP3+Helios+ Regulatory T Cells, Immune Activation, and Advancing Disease in HIV-Infected Children.Journal of acquired immune deficiency syndromes (1999) 2016 · CEBM Level 4
- Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity.Immunity 2016 · CEBM Level 5
- Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics.Trends in biotechnology 2016 · CEBM Level 5
- HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets.PloS one 2016 · CEBM Level 4
- Time of Initiating Enzyme Replacement Therapy Affects Immune Abnormalities and Disease Severity in Patients with Gaucher Disease.PloS one 2016 · CEBM Level 4
- STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.The Journal of clinical investigation 2015 · CEBM Level 5
- Elimination of HIV-1-Infected Primary T Cell Reservoirs in an In Vitro Model of Latency.PloS one 2015 · CEBM Level 5
- Inhibition of HIV infection by caerin 1 antimicrobial peptides.Peptides 2015 · CEBM Level 5
- Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.Journal of immunology (Baltimore, Md. : 1950) 2015 · CEBM Level 5
- Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.The Journal of experimental medicine 2014 · CEBM Level 5
- Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.Journal of immunology (Baltimore, Md. : 1950) 2014 · CEBM Level 5
- Clinical trial evidence of the antitumor activity of topical imiquimod for breast cancer skin metastases.Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 · CEBM Level 5
- CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.Nature 2013 · CEBM Level 5
- Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors.PloS one 2013 · CEBM Level 5
- GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.Journal of immunology (Baltimore, Md. : 1950) 2013 · CEBM Level 5
- Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.Journal of immunology (Baltimore, Md. : 1950) 2013 · CEBM Level 5
- Turkey must end violent response to protests.Science (New York, N.Y.) 2013 · CEBM Level 5
- Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection.Cell host & microbe 2013 · CEBM Level 5
- The metalloprotease ADAM12 regulates the effector function of human Th17 cells.PloS one 2013 · CEBM Level 5
- Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.Journal of virology 2012 · CEBM Level 5
- Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer.Clinical cancer research : an official journal of the American Association for Cancer Research 2012 · CEBM Level 4
- Revisiting immune exhaustion during HIV infection.Current HIV/AIDS reports 2011 · CEBM Level 5
- Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis.Molecular microbiology 2011 · CEBM Level 5
- Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells.The Journal of experimental medicine 2011 · CEBM Level 5
- Expression and function of TNF and IL-1 receptors on human regulatory T cells.PloS one 2010 · CEBM Level 5
- Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.PloS one 2010 · CEBM Level 5
- Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.The Journal of infectious diseases 2010 · CEBM Level 4
- Flexible use of nuclear import pathways by HIV-1.Cell host & microbe 2010 · CEBM Level 5
- Th17 cells and HIV infection.Current opinion in HIV and AIDS 2010 · CEBM Level 5
- A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.Nature 2010 · CEBM Level 5
- CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation.Journal of immunology (Baltimore, Md. : 1950) 2009 · CEBM Level 5
- Differences in APOBEC3G expression in CD4+ T helper lymphocyte subtypes modulate HIV-1 infectivity.PLoS pathogens 2009 · CEBM Level 5
- Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions.The Journal of investigative dermatology 2009 · CEBM Level 5
- Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.Science (New York, N.Y.) 2009 · CEBM Level 5
- RORC2: the master of human Th17 cell programming.European journal of immunology 2009 · CEBM Level 5
- GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.Proceedings of the National Academy of Sciences of the United States of America 2009 · CEBM Level 5
- Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.Proceedings of the National Academy of Sciences of the United States of America 2009 · CEBM Level 5
- The gut feeling of Treg cells: IL-10 is the silver lining during colitis.Nature immunology 2009 · CEBM Level 5
- The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer.Advances in experimental medicine and biology 2009 · CEBM Level 5
- Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis.The Journal of investigative dermatology 2008 · CEBM Level 4
- IRF1: a deus ex machina in TH1 differentiation.Nature immunology 2008 · CEBM Level 5
- Naive precursors of human regulatory T cells require FoxP3 for suppression and are susceptible to HIV infection.Journal of immunology (Baltimore, Md. : 1950) 2008 · CEBM Level 5
- The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat.Nature immunology 2008 · CEBM Level 5
- FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo.Blood 2008 · CEBM Level 5
- Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.PloS one 2008 · CEBM Level 5
- Suppression of HIV-specific and allogeneic T cell activation by human regulatory T cells is dependent on the strength of signals.PloS one 2008 · CEBM Level 5
- Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel.Lab on a chip 2008 · CEBM Level 5
- Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin.Infection and immunity 2007 · CEBM Level 5
- Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells.Journal of immunology (Baltimore, Md. : 1950) 2007 · CEBM Level 5
- Identification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection.PLoS pathogens 2007 · CEBM Level 5
- Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets.Journal of immunology (Baltimore, Md. : 1950) 2007 · CEBM Level 5
- Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.The Journal of clinical investigation 2006 · CEBM Level 5
- Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells.Molecular and cellular biology 2006 · CEBM Level 5
- Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny.Immunity 2006 · CEBM Level 5
- Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study.The Journal of infectious diseases 2006 · CEBM Level 3
- Helicobacter pylori VacA toxin inhibits human immunodeficiency virus infection of primary human T cells.Journal of virology 2006 · CEBM Level 5
- Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.Molecular cell 2006 · CEBM Level 5
- Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions.PloS one 2006 · CEBM Level 5
- Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor.Journal of virology 2005 · CEBM Level 5
- Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.Journal of immunology (Baltimore, Md. : 1950) 2005 · CEBM Level 5
- Nanoparticulate system for efficient gene transfer into refractory cell targets.Biomacromolecules 2005 · CEBM Level 5
- The innate immune system and HIV pathogenesis.Current HIV/AIDS reports 2005 · CEBM Level 5
- Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells.Blood 2005 · CEBM Level 5
- Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.Journal of virology 2005 · CEBM Level 5
- APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.The Journal of biological chemistry 2004 · CEBM Level 5
- Murine T cells potently restrict human immunodeficiency virus infection.Journal of virology 2004 · CEBM Level 5