Approximately 30% of frontotemporal dementia cases are genetic or familial, while 70% of cases are sporadic.
"I know that for, you know, 30%, it can be in genetics, you know, you can see this or within the family, and you can see it through a grandmother, a brother, and, you know, you can see sort of that lineage. And then for, you know, 70% of people with FTD, it's sporadic, meaning it just can happen" (said at 0:39:57)
Published reviews and epidemiological data on frontotemporal dementia (FTD) confirm that approximately 30% to 40% of FTD cases are familial or heritable, while the remaining 60% to 70% are sporadic.
- supports: Approaches to develop therapeutics to treat frontotemporal dementia. (Neuropharmacology 2020)
"While 60-70% of FTD patients are sporadic cases, the other 30-40% are heritable (familial) cases linked to mutations in several known genes." (abstract, passage verified)
pubmedfull study (doi) - supports: Analysis of Heritability Across the Clinical Phenotypes of Frontotemporal Dementia and the… (Frontiers in neurology 2021)
"Frontotemporal dementia (FTD) is a highly heritable condition. Up to 40% of FTD is familial and an estimated 15% to 40% is due to single-gene mutations." (abstract, passage verified)
pubmedfull study (doi)