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Frans Kuypers

Frans Kuypers is a biomedical researcher working in hematology, cellular metabolism, and stem cell biology. His research includes investigating the human placenta as a source of pluripotent and hematopoietic stem cells capable of differentiating into various cell types. His published work focuses extensively on sickle cell disease therapeutics, erythrocyte properties and deformability, and lipid metabolism.

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What they said on air - citing their own research

1 citing their own research

0:09:20supportedlowtheir own paperDr. Frans Kuypers on Placenta as a Source of Bankable Stem C

Frans Kuypers published papers in 2009 and 2012 demonstrating that cells isolated from human term placenta can be cultured to differentiate into multiple cell types such as neurons and heart cells.

"And yes, we have shown in 2009, the paper that you refer to, but we had another paper in 2012 that really shows that in the human term placenta—so this is the placenta that is normally thrown out... you can tease out of those placentas cells that can become any kind of cell in your body." (said at 0:09:20)

Frans Kuypers and colleagues published studies in 2009 and 2012 demonstrating that cells isolated from human term placenta can generate multiple cell lineages. The 2009 study isolated CD34-positive hematopoietic stem and progenitor cells from term placenta that generated erythroid, myeloid, and lymphoid lineages. The 2012 study isolated human chorionic mesenchymal stem cells (hCMSCs) expressing embryonic stem cell markers (such as OCT-4 and NANOG) that demonstrated in vitro differentiation into cell types representing all three germ layers, including neuron-like cells (ectoderm), adipocytes/osteoblasts/endothelial-like cells (mesoderm), and hepatocytes (endoderm).

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