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Guido Kroemer

University of Paris Descartes

Guido Kroemer is a professor at the University of Paris Descartes specializing in immunology, cancer biology, aging, and autophagy. His research investigates mechanisms of regulated cell death, including apoptosis, ferroptosis, and immunogenic cell death. His publications also explore cancer immunotherapy, gut microbiota interventions in oncology, and therapeutic targets in metabolic and age-related diseases.

38 claims checked on air: 3 context 1 contradicted 2 overstated 28 supported 4 unverified 3 flagged

What they said on air - contradicted

0:33:32contradictedhighDr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics

Yeast cells placed in a glucose medium shift from oxidative phosphorylation to glycolysis by destroying most of their mitochondria through mitophagy.

"The easiest example is yeast that you suddenly place in a glucose-containing medium to allow for the fermentation of glucose in wine or beer production. So these yeast cells don't need much oxidative phosphorylation and they essentially rely during the process on glycolysis. So they adapt to this change by destroying most of their mitochondria by mitophagy." (said at 0:33:32)

The claim states that transferring yeast to a glucose-containing medium causes the cells to adapt by destroying most of their mitochondria through mitophagy. In Saccharomyces cerevisiae, high-glucose conditions actually repress and suppress mitophagy (for example, by maintaining low expression of the essential mitophagy receptor Atg32). Conversely, mitophagy is induced by glucose starvation, carbon depletion (such as ethanol depletion), or stationary phase growth, rather than by glucose exposure.

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