HoldsUp

Judith Campisi

Buck Institute for Research on Aging

Judith Campisi, Ph.D., is a professor of biogerontology at the Buck Institute for Research on Aging and a co-editor in chief of the journal Aging. Her research focuses on cellular senescence and its roles in the aging process and cancer development. Her published studies investigate mechanisms such as DNA damage, the senescence-associated secretory phenotype (SASP), senotherapeutic strategies, and the impact of senescent cells across various tissues and age-related conditions.

32 claims checked on air: 4 context 2 overstated 25 supported 1 unverified 2 flagged

What they said on air - unverified

2 citing their own research

0:38:46unverifiedvery lowJudith Campisi, Ph.D. on Cellular Senescence, Mitochondrial

In aged mouse skin, clearing senescent cells provides little regenerative benefit because the stem cell pool has already been depleted.

"So we have shown in the skin, for example, that with age, um senescent cells do accumulate, but if you clear those cells, you don't get much benefit and that's because by old age, you've depleted the stem cells." (said at 0:38:46)

No published record matching the claim that clearing senescent cells from aged mouse skin provides little regenerative benefit due to exhaustion or depletion of the stem cell pool was located; this does not prove the claim false. While published mouse models from the Campisi laboratory demonstrate that senescent fibroblasts and endothelial cells transiently promote cutaneous wound healing via PDGF-AA secretion (and that their clearance can delay acute wound repair), the specific finding that senolytic clearance fails to rejuvenate aged skin because of stem cell pool depletion has not been documented in the indexed literature.

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