Michael Snyder
Stanford University
Michael Snyder is the chair of the Department of Genetics and director of the Center for Genomics and Personalized Medicine at Stanford University. His work focuses on personalized medicine, big data, and deep profiling using wearable technology. His published research covers multi-omics analysis, single-cell genomics and proteomics, continuous glucose monitoring, and transcriptomic regulation in human disease.
30 claims checked on air: 2 context 1 contradicted 1 overstated 26 supported 2 flagged
What they said on air - overstated
Following antibiotic use, the gut microbiome shifts but generally bounces back to its baseline composition after cessation of the antibiotic.
"If you take an antibiotic, you'll shift it, but then it bounces right back, believe it or not, as soon as you go off the antibiotic." (said at 1:01:50)
While the gut microbiome possesses ecological resilience and often shifts back toward baseline composition following antibiotic cessation, recovery is not immediate and is frequently incomplete. Prospective human studies demonstrate that recovery to near-baseline composition typically requires weeks to months, rather than occurring immediately upon stopping the drug. Furthermore, recovery trajectories vary substantially depending on the antibiotic class, baseline microbiome composition, and host factors; certain taxa may remain permanently depleted or undetectable for months, and antibiotic resistance genes can persist long after treatment ends.
- contradicts: Short- and long-term effects of oral vancomycin on the human intestinal microbiota. (The Journal of antimicrobial chemotherapy 2017) · cited 322x in the literature
"Following antibiotic cessation, marked differences in microbiota resilience were observed among subjects. While some individuals recovered a microbiota close to baseline composition, in others, up to 89% of abundant OTUs could no longer be detected." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Gut Bacterial Microbiota and its Resistome Rapidly Recover to Basal State Levels after Sho… (Scientific reports 2018) · cited 111x in the literature
"Despite perturbations caused by short-term antibiotic treatment, both gut microbiota and resistome showed prompt recovery to baseline levels one week after cessation of the antimicrobial." (abstract, results, passage verified)
pubmedfull study (doi) - context: Recovery of gut microbiota of healthy adults following antibiotic exposure. (Nature microbiology 2018) · cited 894x in the literature
"The gut microbiota of the subjects recovered to near-baseline composition within 1.5 months, although 9 common species, which were present in all subjects before the treatment, remained undetectable in most of the subjects after 180 days." (abstract, results, passage verified)
pubmedfull study (doi)
Fact-checked episodes
Publications
- Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases.Nature biotechnology 2026 · CEBM Level 5
- Whole-genome variant detection in long-read sequencing data from ultra-low input patient samples.medRxiv : the preprint server for health sciences 2026 · CEBM Level 4
- Glucose360: An Open-Source Python Platform with Event-Based Integration for Continuous Glucose Monitoring Data Analysis.Diabetes technology & therapeutics 2026 · CEBM Level 5
- The nascent transcriptome delineates the regulatory landscape in human health and disease.bioRxiv : the preprint server for biology 2026 · CEBM Level 5
- Multi-omics analysis of a pig-to-human decedent kidney xenotransplant.Nature 2026 · CEBM Level 4
- Polyclonal origins of human premalignant colorectal lesions.Nature 2026 · CEBM Level 4
- An expanded registry of candidate cis-regulatory elements.Nature 2026 · CEBM Level 5
- Research Code Sharing in Support of Gold Standard Science.Journal of diabetes science and technology 2026 · CEBM Level 5
- Navigating open data sharing and privacy in the age of clinical AI research: from reidentification to pseudo-reidentification.EClinicalMedicine 2026 · CEBM Level 5
- Integrative epigenetics and transcriptomics identify aging genes in human blood.Nature communications 2026 · CEBM Level 4
- Harnessing phytochemicals for engineering health solutions.Human genomics 2026 · CEBM Level 5
- An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk.Cell reports. Medicine 2026 · CEBM Level 3
- Single-cell proteomic landscape of the developing human brain.Nature biotechnology 2026 · CEBM Level 5
- Leveraging health records to identify diagnoses associated with recurrent pregnancy loss across two medical centers.iScience 2026 · CEBM Level 4
- Modifiable Factors Affecting the Postprandial Glycemic Response.Journal of diabetes science and technology 2026 · CEBM Level 5
- Diet-based weight-loss intervention is not associated with a meaningful change in lean soft tissue.The American journal of clinical nutrition 2026 · CEBM Level 2
- Integrating trust into artificial intelligence for medicine: using diabetes as the exemplar disease.Journal of translational medicine 2026 · CEBM Level 5
- Insulin resistance modifies longitudinal multi-omics responses to habitual diet.bioRxiv : the preprint server for biology 2026 · CEBM Level 3
- The Human Intolerome: A curated database to prioritize genomic variants in stillbirth, pregnancy loss, and neonatal death.Genetics in medicine : official journal of the American College of Medical Genetics 2026 · CEBM Level 5
- Integrating the Glycemia Risk Index Into Clinical Practice and Research: A Consensus Report.Journal of diabetes science and technology 2026 · CEBM Level 5
- Muscle movement and metabolism: exercise and skeletal muscle as mediators of health-a report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.The American journal of clinical nutrition 2026 · CEBM Level 5
- Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.Nature communications 2026 · CEBM Level 5
- Single-cell spatiotemporal dissection of the human maternal-fetal interface.Nature 2026 · CEBM Level 5
- Cross-body site microbial interactions influence the human plasma metabolome.Microbiome 2026 · CEBM Level 4
- The Digital Physical Exam: A Pilot Exploring the Utility of Smartphone and Smartwatch Wearable Data for Hospital Medicine.Digital biomarkers 2026 · CEBM Level 4
- Use of Continuous Glucose Monitoring With Machine Learning to Identify Metabolic Subphenotypes and Inform Precision Lifestyle Changes.Journal of diabetes science and technology 2026 · CEBM Level 5
- In Depth Characterization of the Promoter Proximal Proteome of Single Copy Locus FOXP2.Molecular & cellular proteomics : MCP 2026 · CEBM Level 5
- A comparison of deep multiomics profiles across ethnicity, geography, and age.Cell 2026 · CEBM Level 4
- Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium.bioRxiv : the preprint server for biology 2026 · CEBM Level 2
- A Multimodal Framework for Organ- and Cell-Resolved Biological Aging and Longevity Intervention Discovery.medRxiv : the preprint server for health sciences 2026 · CEBM Level 3
- Whole-genome variant detection in long-read sequencing data from ultralow input patient samples.Genome research 2026 · CEBM Level 5
- Machine Learning Reveals the Contribution of Rare Genetic Variants and Enhances Risk Prediction for Coronary Artery Disease in the Japanese Population.Circulation. Genomic and precision medicine 2026 · CEBM Level 4
- Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases.bioRxiv : the preprint server for biology 2026 · CEBM Level 4
- Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytes.Research square 2026 · CEBM Level 4
- Power and sample-size estimation in human microbiome research.Med (New York, N.Y.) 2026 · CEBM Level 5
- Spatial distribution of the proteome in the human body and in cancers.Nature 2026 · CEBM Level 4
- The gut microbiome of a Northern Plains tribe is in transition between global Indigenous and industrialized populations.Cell reports 2026 · CEBM Level 4
- Reply to I Jannasz et al: DIETFITS cohort, modeling, and molecules.The American journal of clinical nutrition 2026 · CEBM Level 5
- Fault-tolerant 3D reconstruction from 2D spatial proteomics sections.bioRxiv : the preprint server for biology 2026 · CEBM Level 5
- LOESS and DE-SWAN can induce artifactual "waves" of molecular aging.bioRxiv : the preprint server for biology 2026 · CEBM Level 5
- MetaboNet-Bench: A Multi-modal Benchmark for Glucose Forecasting in Type 1 Diabetes.ArXiv 2026 · CEBM Level 5
- Autonomous biomedical research with an artificial intelligence agent.Science (New York, N.Y.) 2026 · CEBM Level 5
- Multiscale harmonization and semantic integration of biomedical data enable biological insights through immersive exploration.bioRxiv : the preprint server for biology 2026 · CEBM Level 5
- Human body single-cell atlas of three-dimensional genome organization and DNA methylation.Science (New York, N.Y.) 2026 · CEBM Level 4
- INSIGHT: Ingest and Standardize Glucose Harmonization Tool.Journal of diabetes science and technology 2026 · CEBM Level 5
- Inflammatory Proteins are Highly Variable During a Natural Stressor: A Call for Intensive Longitudinal Blood Microsampling.Brain, behavior, and immunity 2026 · CEBM Level 3
- Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging.Science advances 2026 · CEBM Level 5
- Neuroinflammation as molecular landscape of post-operative delirium revealed by live human brain multi-omics profiling.Molecular psychiatry 2026 · CEBM Level 4
- Temporal multi-omic analysis uncovers sex-biased molecular programs underlying skeletal muscle adaptation to endurance training.Cell reports 2026 · CEBM Level 5
- Single-Cell Proteomics Uncovers Cell-Specific Proteins in Vascular Health and Marfan Syndrome Disease.Arteriosclerosis, thrombosis, and vascular biology 2026 · CEBM Level 4
- The effect of sex and endurance exercise training on the incretin signaling pathway in 17 rat tissues.Physiological genomics 2026 · CEBM Level 5
- A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.Immunity 2026 · CEBM Level 4
- Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning.Nature biomedical engineering 2025 · CEBM Level 3
- Commentary: Molecular responses in pig heart to human xenotransplantation unveiled by longitudinal multi-omic profiling.Clinical and translational medicine 2025 · CEBM Level 5
- Impact of digital health interventions on glycemic control and weight management.NPJ digital medicine 2025 · CEBM Level 3
- Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression.Nature metabolism 2025 · CEBM Level 5
- Prevalence of Adverse Childhood Experience Exposure by Disability Status.JAMA health forum 2025 · CEBM Level 4
- VISTA-induced tumor suppression by a four amino acid intracellular motif.bioRxiv : the preprint server for biology 2025 · CEBM Level 5
- Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons.BMC medical genomics 2025 · CEBM Level 4
- Author Correction: Considerations in the search for epistasis.Genome biology 2025 · CEBM Level 5
- A Pilot Study Exploring the Relationship Between Milk Composition and Microbial Capacity in Breastfed Infants.Nutrients 2025 · CEBM Level 4
- The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots.Nature communications 2025 · CEBM Level 5
- Author Correction: Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis.Nature cancer 2025 · CEBM Level 5
- Regulation of protein abundance in normal human tissues.medRxiv : the preprint server for health sciences 2025 · CEBM Level 4
- Exposomics: a review of methodologies, applications, and future directions in molecular medicine.EMBO molecular medicine 2025 · CEBM Level 5
- Publisher Correction: The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles.Genome biology 2025 · CEBM Level 5
- Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients.bioRxiv : the preprint server for biology 2025 · CEBM Level 4
- Invigorating discovery and clinical translation of aging biomarkers.Nature aging 2025 · CEBM Level 5
- Human Body Single-Cell Atlas of 3D Genome Organization and DNA Methylation.bioRxiv : the preprint server for biology 2025 · CEBM Level 5
- Microbiome-Immune Interaction in Pulmonary Arterial Hypertension: What Have We Missed?Research (Washington, D.C.) 2025 · CEBM Level 5
- Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension.Respiratory research 2025 · CEBM Level 4
- Precision nutrition for cardiometabolic diseases.Nature medicine 2025 · CEBM Level 5
- Advancing translational exposomics: bridging genome, exposome and personalized medicine.Human genomics 2025 · CEBM Level 5
- Embracing Interpersonal Variability of Microbiome in Precision Medicine.Phenomics (Cham, Switzerland) 2025 · CEBM Level 5
- Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis.medRxiv : the preprint server for health sciences 2025 · CEBM Level 4
- Predicting Placenta Accreta Spectrum Disorder Through Machine Learning Using Metabolomic and Lipidomic Profiling and Clinical Characteristics.Obstetrics and gynecology 2025 · CEBM Level 4
- Emerging Technologies and Future Directions in Interorgan Crosstalk Cardiometabolic Research.Circulation research 2025 · CEBM Level 5
- Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology.Nature medicine 2025 · CEBM Level 3
- High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes.NPJ digital medicine 2025 · CEBM Level 3
- Biomni: A General-Purpose Biomedical AI Agent.bioRxiv : the preprint server for biology 2025 · CEBM Level 5
- ProMix: Enhancing Protein Quantification through Experimental Design and Statistical Normalization.Journal of proteome research 2025 · CEBM Level 5
- Oxidative stress is a shared characteristic of ME/CFS and Long COVID.Proceedings of the National Academy of Sciences of the United States of America 2025 · CEBM Level 4
- Metabolomic Profiles During and After a Hypertensive Disorder of Pregnancy: The EPOCH Study.International journal of molecular sciences 2025 · CEBM Level 4
- A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression.Cancer research 2025 · CEBM Level 5
- Continuous Glucose Monitoring Data Analysis 2.0: Functional Data Pattern Recognition and Artificial Intelligence Applications.Journal of diabetes science and technology 2025 · CEBM Level 5
- Achieving inclusive healthcare through integrating education and research with AI and personalized curricula.Communications medicine 2025 · CEBM Level 4
- Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.Cell stem cell 2025 · CEBM Level 5
- A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.Cell reports 2025 · CEBM Level 4
- The Biological Variation in Serum ACE and CPN/CPB2 Activity in Healthy Individuals as Measured by the Degradation of Dabsylated Bradykinin-Reference Data and the Importance of Pre-Analytical Standardization.Proteomes 2025 · CEBM Level 4
- Patterns of Organ-Specific Proteomic Aging in Relation to Lifestyle, Diseases, and Mortality.Aging cell 2025 · CEBM Level 3
- Optimised machine learning for time-to-event prediction in healthcare applied to timing of gastrostomy in ALS: a multi-centre, retrospective model development and validation study.EBioMedicine 2025 · CEBM Level 3
- Molecular Mechanisms of Exosomes From Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells in Restoring the Injured Myocardium.Journal of the American Heart Association 2025 · CEBM Level 5
- Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.Cell 2025 · CEBM Level 4
- A unified framework for systematic curation and evaluation of aging biomarkers.Nature aging 2025 · CEBM Level 3
- Genetic Variants in Recurrent Euploid Pregnancy Loss.medRxiv : the preprint server for health sciences 2025 · CEBM Level 4
- Longitudinal wearable sensor data enhance precision of Long COVID detection.PLOS digital health 2025 · CEBM Level 3
- Polyclonal origins of human premalignant colorectal lesions.bioRxiv : the preprint server for biology 2025 · CEBM Level 4
- Maternal lipidomic signatures of preterm and small-for-gestational-age newborn infants in low- and middle-income countries.Science advances 2025 · CEBM Level 3
- Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance Training.bioRxiv : the preprint server for biology 2025 · CEBM Level 5
- Improving design and normalization of multiplex proteomics study.bioRxiv : the preprint server for biology 2024 · CEBM Level 5
- An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation.bioRxiv : the preprint server for biology 2024 · CEBM Level 5
- Longitudinal urine metabolic profiling and gestational age prediction in human pregnancy.Briefings in bioinformatics 2024 · CEBM Level 3