Paul Fernyhough
Paul Fernyhough is a researcher in the field of neuroscience with a focus on peripheral nerve disorders. His published research investigates mechanisms and treatments for diabetic peripheral neuropathy, mitochondrial dysfunction, and neuritogenesis. In particular, his work explores the therapeutic potential of muscarinic acetylcholine receptor antagonists to stimulate axonal repair and neurite outgrowth in sensory neurons.
8 claims checked on air: 7 supported 1 unverified
What they said on air - unverified
3 citing their own research
Human tissue samples from patients with chemotherapy-induced neuropathy, HIV neuropathy, and diabetic neuropathy show mitochondrial abnormalities.
"And it's been shown in a number of peripheral neuropathies, certainly in chemotherapy-induced neuropathy, and I think HIV that there are in human samples mitochondrial abnormalities, and the same is true in diabetes." (said at 0:18:00)
No published record matching the claim that human tissue samples across chemotherapy-induced neuropathy, HIV neuropathy, and diabetic neuropathy show mitochondrial abnormalities was located; this does not prove the claim false.
Fact-checked episodes
Publications
- Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy.EBioMedicine 2026 · CEBM Level 2
- Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis.Science signaling 2026 · CEBM Level 5
- Corrigendum to "Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents" [Mol. Cell. Neurosci. Volume 90, July 2018, Pages 49-59].Molecular and cellular neurosciences 2026 · CEBM Level 5
- Discovery of VU6077564: A Selective M 1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.ACS chemical neuroscience 2026 · CEBM Level 5
- Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons.Molecular metabolism 2025 · CEBM Level 5
- Estradiol activates the CaMKKβ/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons.Molecular and cellular neurosciences 2025 · CEBM Level 5
- Estradiol Prevents Amyloid Beta-Induced Mitochondrial Dysfunction and Neurotoxicity in Alzheimer's Disease via AMPK-Dependent Suppression of NF-κB Signaling.International journal of molecular sciences 2025 · CEBM Level 5
- Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy.International journal of molecular sciences 2025 · CEBM Level 5
- A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin.Acta neuropathologica 2024 · CEBM Level 2
- Oxidative Stress and Mitochondrial Dysfunction Associated with Peripheral Neuropathy in Type 1 Diabetes.Antioxidants & redox signaling 2022 · CEBM Level 5
- CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.Cellular and molecular life sciences : CMLS 2022 · CEBM Level 5
- Development of iPSC-based clinical trial selection platform for patients with ultrarare diseases.Science advances 2022 · CEBM Level 4
- Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons.Molecular neurobiology 2022 · CEBM Level 5
- Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system.Expert review of neurotherapeutics 2021 · CEBM Level 5
- Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology 2021 · CEBM Level 5
- Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1.Molecular metabolism 2021 · CEBM Level 5
- Activation of Cannabinoid Receptors Attenuates Endothelin-1-Induced Mitochondrial Dysfunction in Rat Ventricular Myocytes.Journal of cardiovascular pharmacology 2020 · CEBM Level 5
- Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment.Cancers 2020 · CEBM Level 4
- Muscarinic Toxin 7 Signals Via Ca 2+ /Calmodulin-Dependent Protein Kinase Kinase β to Augment Mitochondrial Function and Prevent Neurodegeneration.Molecular neurobiology 2020 · CEBM Level 5
- Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice.The Journal of pharmacology and experimental therapeutics 2020 · CEBM Level 5
- Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer's Mice.Cells 2020 · CEBM Level 5
- Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer's Disease.Nutrients 2020 · CEBM Level 5
- Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes.Molecular metabolism 2019 · CEBM Level 5
- Preface.International review of neurobiology 2019 · CEBM Level 5
- Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons.Neuropharmacology 2019 · CEBM Level 5
- Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189.Diabetes 2019 · CEBM Level 5
- Chronic dietary creatine enhances hippocampal-dependent spatial memory, bioenergetics, and levels of plasticity-related proteins associated with NF-κB.Learning & memory (Cold Spring Harbor, N.Y.) 2018 · CEBM Level 5
- Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior.Stem cell research & therapy 2018 · CEBM Level 5
- Depressed mitochondrial function and electron transport Complex II-mediated H 2 O 2 production in the cortex of type 1 diabetic rodents.Molecular and cellular neurosciences 2018 · CEBM Level 5
- Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons.Frontiers in neuroscience 2018 · CEBM Level 5
- High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.Experimental neurology 2018 · CEBM Level 5
- Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons.Neuropharmacology 2018 · CEBM Level 5
- Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy.The Journal of clinical investigation 2017 · CEBM Level 5
- A model of chronic diabetic polyneuropathy: benefits from intranasal insulin are modified by sex and RAGE deletion.American journal of physiology. Endocrinology and metabolism 2017 · CEBM Level 5
- Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer's disease.Neuroscience 2017 · CEBM Level 5
- Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats.Experimental neurology 2017 · CEBM Level 5
- Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs.Intensive care medicine experimental 2016 · CEBM Level 5
- Rabies virus phosphoprotein interacts with mitochondrial Complex I and induces mitochondrial dysfunction and oxidative stress.Journal of neurovirology 2015 · CEBM Level 5
- The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats.Experimental neurology 2015 · CEBM Level 5
- Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events.Current diabetes reports 2015 · CEBM Level 5
- Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria.Bioscience reports 2015 · CEBM Level 5
- Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents.Cellular and molecular neurobiology 2014 · CEBM Level 5
- Temporal dystrophic remodeling within the intrinsic cardiac nervous system of the streptozotocin-induced diabetic rat model.Acta neuropathologica communications 2014 · CEBM Level 5
- Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies.Cell calcium 2014 · CEBM Level 5
- Mechanisms of disease: Mitochondrial dysfunction in sensory neuropathy and other complications in diabetes.Handbook of clinical neurology 2014 · CEBM Level 5
- Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.Proceedings of the National Academy of Sciences of the United States of America 2014 · CEBM Level 5
- The role of aberrant mitochondrial bioenergetics in diabetic neuropathy.Neurobiology of disease 2013 · CEBM Level 5
- Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents.Neuropharmacology 2013 · CEBM Level 5
- Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy.Journal of medicinal chemistry 2013 · CEBM Level 5
- Receptor for advanced glycation end-products (RAGE) activates divergent signaling pathways to augment neurite outgrowth of adult sensory neurons.Experimental neurology 2013 · CEBM Level 5
- Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons.Molecular brain 2013 · CEBM Level 5
- Mitochondrial dysfunction in rabies virus infection of neurons.Journal of neurovirology 2013 · CEBM Level 5
- Sensory neurons derived from diabetic rats have diminished internal Ca2+ stores linked to impaired re-uptake by the endoplasmic reticulum.ASN neuro 2012 · CEBM Level 5
- Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes.Brain : a journal of neurology 2012 · CEBM Level 5
- Role of nuclear factor-κB in oxidative stress associated with rabies virus infection of adult rat dorsal root ganglion neurons.Journal of virology 2012 · CEBM Level 5
- Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats.Diabetes 2011 · CEBM Level 5
- Role of oxidative stress in rabies virus infection.Advances in virus research 2011 · CEBM Level 5
- Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes.Mitochondrion 2011 · CEBM Level 5
- Tumor necrosis factor-α elevates neurite outgrowth through an NF-κB-dependent pathway in cultured adult sensory neurons: Diminished expression in diabetes may contribute to sensory neuropathy.Brain research 2011 · CEBM Level 5
- 4-Hydroxy-2-nonenal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy.Neurotoxicity research 2010 · CEBM Level 5
- Abnormal calcium homeostasis in peripheral neuropathies.Cell calcium 2010 · CEBM Level 5
- Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment.Diabetes 2010 · CEBM Level 5
- Role of oxidative stress in rabies virus infection of adult mouse dorsal root ganglion neurons.Journal of virology 2010 · CEBM Level 5
- Mitochondrial stress and the pathogenesis of diabetic neuropathy.Expert review of endocrinology & metabolism 2010 · CEBM Level 5
- Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress.Diabetes 2009 · CEBM Level 5
- Nuclear factor-kappaB activation in axons and Schwann cells in experimental sciatic nerve injury and its role in modulating axon regeneration: studies with etanercept.Journal of neuropathology and experimental neurology 2009 · CEBM Level 5
- Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats.Journal of magnetic resonance imaging : JMRI 2009 · CEBM Level 5
- Mitochondrial malfunction and Ca2+ dyshomeostasis drive neuronal pathology in diabetes.Cell calcium 2008 · CEBM Level 5
- Growth factors as therapeutics for diabetic neuropathy.Current drug targets 2008 · CEBM Level 5
- Blockade of hexokinase activity and binding to mitochondria inhibits neurite outgrowth in cultured adult rat sensory neurons.Neuroscience letters 2008 · CEBM Level 5
- Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model.Diabetes 2008 · CEBM Level 5
- Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin.Molecular and cellular neurosciences 2007 · CEBM Level 5
- Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells.The European journal of neuroscience 2007 · CEBM Level 5
- Expression of hexokinase isoforms in the dorsal root ganglion of the adult rat and effect of experimental diabetes.Brain research 2007 · CEBM Level 5
- Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons.Molecular and cellular neurosciences 2005 · CEBM Level 5
- Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons.Molecular and cellular neurosciences 2005 · CEBM Level 5
- Activation of nuclear factor-kappaB via endogenous tumor necrosis factor alpha regulates survival of axotomized adult sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 · CEBM Level 5
- Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia.Diabetes 2003 · CEBM Level 5
- Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.Diabetes 2003 · CEBM Level 5
- Peripheral axon crush elevates transport of p75NTR in the central projection of sensory neurones of rats.Neuroscience letters 2003 · CEBM Level 5
- Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy.Journal of the peripheral nervous system : JPNS 2003 · CEBM Level 5
- Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro.Annals of the New York Academy of Sciences 2003 · CEBM Level 5
- Neurofilaments in diabetic neuropathy.International review of neurobiology 2002 · CEBM Level 5