Robin Carhart-Harris
Robin Carhart-Harris is a neuroscientist specializing in psychedelic research and psychedelic psychiatry. His research investigates the neurobiological mechanisms and clinical applications of substances such as psilocybin, LSD, MDMA, DMT, and ketamine. His published work focuses on their therapeutic potential for conditions like major depressive disorder, as well as their effects on brain connectivity, neuroplasticity, and subjective experience.
25 claims checked on air: 1 contradicted 2 overstated 18 supported 4 unverified
What they said on air - unverified
2 citing their own research
Psychologist Betty Eisner introduced the concept of the psychosocial matrix in the 1960s as a third factor alongside set and setting in psychedelic therapy.
"Back in the '60s, I believe it was a psychologist, Betty Eisner, brought in a third component, which she called matrix, the psychosocial matrix." (said at 0:55:15)
No published record matching the claim that psychologist Betty Eisner introduced the concept of the 'psychosocial matrix' (or matrix) as a third factor alongside set and setting in the 1960s was located; this does not prove the claim false.
Evidence for psychedelic-induced neuroplasticity is primarily based on rodent studies, with human evidence not yet clearly established.
"Well, in mice. But human evidence of neuroplasticity, it ain't really there yet. You know, we're working on it. We'll have some brain imaging markers of it quite soon. Um, but the whole story is based on work in little mice brains and not much else, to be honest." (said at 1:03:11)
No published record matching the claim that evidence for psychedelic-induced neuroplasticity is primarily based on rodent studies and not yet clearly established in humans was located; this does not prove the claim false.
Psilocybin has not worked well for Alzheimer's disease because patients cannot remember their experience or trip.
"Alzheimer's, you know, there's been a little bit of work. People can't remember their trip. They can't remember the experience, and so it hasn't worked that well so far." (said at 1:06:07)
No published record matching the claim that psilocybin has failed or proved ineffective in Alzheimer's disease because patients cannot remember their psychedelic experience was located; this does not prove the claim false. Published literature on psilocybin and other psychedelics in Alzheimer's disease remains largely exploratory, comprising preclinical studies, narrative reviews, and theoretical rationales focusing primarily on biological mechanisms (such as 5-HT2A agonism, neuroplasticity, BDNF signaling, and anti-inflammatory effects) and preliminary management of comorbid neuropsychiatric symptoms.
- context: Psychedelics as Novel Therapeutics in Alzheimer's Disease: Rationale and Potential Mechani… (Current topics in behavioral neurosciences 2022) · cited 33x in the literature
"A number of biological mechanisms of action are under investigation to elucidate 5-HT 2A R agonists' therapeutic potential, including enhanced neuroplasticity, anti-inflammatory effects, and alterations in brain functional connectivity." (abstract, results, passage verified)
pubmedfull study (doi) - context: Psilocybin for the treatment of Alzheimer's disease. (Frontiers in neuroscience 2024) · cited 24x in the literature
"Psilocybin, a psychoactive alkaloid intrinsic to hallucinogenic mushrooms, has garnered attention within the neuropsychiatric realm due to its established safety and efficacy in treating depression. Nonetheless, its potential as a therapeutic avenue for AD remains largely uncharted." (abstract, background, passage verified)
pubmedfull study (doi)
Jack Gallant's research team at UC Berkeley has used brain decoding algorithms on neuroimaging data to predict what movies individuals are watching or what audio scripts they are listening to.
"People like Jack Gallant at UC Berkeley have used that approach to predict, um, what people are viewing in terms of movie watching, um, what people are listening to in terms of audio scripts." (said at 1:17:47)
No published record matching Jack Gallant's research team at UC Berkeley using brain decoding algorithms on neuroimaging data to predict what movies individuals are watching or what audio scripts they are listening to was located; this does not prove the claim false.
Fact-checked episodes
Publications
- Corrigendum to "The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression" [Journal of Affective Disorders, Volume 372 (2025), Pages 523-532].Journal of affective disorders 2026 · CEBM Level 2
- Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2026 · CEBM Level 4
- A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · CEBM Level 5
- DMT-Induced Shifts in Criticality Correlate with Self-Dissolution.The Journal of neuroscience : the official journal of the Society for Neuroscience 2026 · CEBM Level 4
- Thresholding and Perfusion Considerations in Interpreting Reduced Brain Responsiveness With Escitalopram: Response to Knudsen et al.The American journal of psychiatry 2026 · CEBM Level 5
- Blunted Psychedelic Drug Effects in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2026 · CEBM Level 5
- The science of psychedelic medicine.Nature medicine 2026 · CEBM Level 5
- A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial.Nature medicine 2026 · CEBM Level 2
- Baseline Mood and "Relational Triad" Predict Acute Qualities of Psychedelic Experience.Behavioral sciences (Basel, Switzerland) 2026 · CEBM Level 3
- The combination of exercise and psychedelics for the treatment of major depressive disorder.Discover mental health 2026 · CEBM Level 5
- Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 · CEBM Level 4
- The role of therapeutic alliance in psilocybin treatment for treatment-resistant depression: A post hoc path analysis.Journal of affective disorders 2026 · CEBM Level 3
- An international mega-analysis of psychedelic drug effects on brain circuit function.Nature medicine 2026 · CEBM Level 3
- Effects of psychedelic use on authoritarian attitudes revisited.Journal of psychopharmacology (Oxford, England) 2026 · CEBM Level 3
- Correction to: Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action.Current psychiatry reports 2026 · CEBM Level 5
- Computational spirits: a neuroscientific account of psychedelic entity encounters.Neuroscience of consciousness 2026 · CEBM Level 5
- The entropic brain today.Brain : a journal of neurology 2026 · CEBM Level 5
- Clinical improvement following an integrative iboga microdosing protocol in post-concussive and hypoxic brain injury syndromes: a case series.Frontiers in pharmacology 2026 · CEBM Level 4
- Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.Human brain mapping 2026 · CEBM Level 4
- Psilocybin therapy for adult females with anorexia nervosa: pilot study.The British journal of psychiatry : the journal of mental science 2026 · CEBM Level 4
- Micro-phenomenology of immersion and perceived presences under DMT.Neuroscience of consciousness 2026 · CEBM Level 4
- Psychedelics Trials and Outcomes-A Closer Look.JAMA psychiatry 2026 · CEBM Level 5
- Well-being as a primary endpoint in clinical trials: a call for consensus.Npj mental health research 2026 · CEBM Level 5
- Psychedelics align brain activity with context.Nature 2026 · CEBM Level 3
- Psilocybin therapy for treatment resistant depression: prediction of clinical outcome by natural language processing.Psychopharmacology 2025 · CEBM Level 2
- 5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?Psychopharmacology 2025 · CEBM Level 5
- Reply to Letter to the Editor: "Psychedelics in Older Adults: Difficulties of a Clear Therapeutic Evidence".The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2025 · CEBM Level 5
- Examining differences in the effects and contexts of naturalistic psilocybin use for White participants vs. Participants of Color: A longitudinal online survey study.Journal of affective disorders 2025 · CEBM Level 3
- The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression.Journal of affective disorders 2025 · CEBM Level 2
- From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS).Scientific reports 2025 · CEBM Level 4
- Study Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.Cureus 2025 · CEBM Level 5
- Correction: Study Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.Cureus 2025 · CEBM Level 5
- A qualitative analysis of the psychedelic mushroom come-up and come-down.Npj mental health research 2025 · CEBM Level 4
- Can psychedelic use benefit meditation practice? Examining individual, psychedelic, and meditation-related factors.PloS one 2025 · CEBM Level 4
- Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).Communications biology 2025 · CEBM Level 5
- Exploring serotonergic psychedelics as a treatment for personality disorders.Neuropharmacology 2025 · CEBM Level 5
- Psilocybin for disorders of consciousness: A case-report study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2025 · CEBM Level 4
- On Minimizing Risk and Harm in the Use of Psychedelics.Psychiatric research and clinical practice 2025 · CEBM Level 5
- Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models.Neuroscience and biobehavioral reviews 2025 · CEBM Level 5
- The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State.Human brain mapping 2025 · CEBM Level 3
- Decreased CO 2 saturation during circular breathwork supports emergence of altered states of consciousness.Communications psychology 2025 · CEBM Level 3
- Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience.Communications biology 2025 · CEBM Level 3
- Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness.Neuroscience of consciousness 2025 · CEBM Level 4
- Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use.PNAS nexus 2025 · CEBM Level 3
- Dissociable effects of psilocybin and escitalopram for depression on processing of musical surprises.Molecular psychiatry 2025 · CEBM Level 2
- Reduced Brain Responsiveness to Emotional Stimuli With Escitalopram But Not Psilocybin Therapy for Depression.The American journal of psychiatry 2025 · CEBM Level 2
- A Field-Wide Review and Analysis of Study Materials Used in Psilocybin Trials: Assessment of Two Decades of Research.Psychedelic medicine (New Rochelle, N.Y.) 2025 · CEBM Level 4
- Correction: Dissociable effects of psilocybin and escitalopram for depression on processing of musical surprises.Molecular psychiatry 2025 · CEBM Level 2
- Human neuroimaging: fMRI.International review of neurobiology 2025 · CEBM Level 5
- Enhanced meaning in life following psychedelic use: converging evidence from controlled and naturalistic studies.Frontiers in psychology 2025 · CEBM Level 3
- The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2025 · CEBM Level 2
- Single-dose (10 mg) psilocybin reduces symptoms in adults with obsessive-compulsive disorder: A pharmacological challenge study.Comprehensive psychiatry 2025 · CEBM Level 3
- Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings.Brain and behavior 2025 · CEBM Level 3
- An investigation of acute physiological and psychological moderators of psychedelic-induced personality change among healthy volunteers.Neuroscience applied 2025 · CEBM Level 3
- Perturbing whole-brain models of brain hierarchy: An application for depression following pharmacological treatment.Annals of the New York Academy of Sciences 2025 · CEBM Level 5
- LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.Imaging neuroscience (Cambridge, Mass.) 2025 · CEBM Level 3
- Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self.Imaging neuroscience (Cambridge, Mass.) 2025 · CEBM Level 4
- Improved mental health outcomes and normalised spontaneous EEG activity in veterans reporting a history of traumatic brain injuries following participation in a psilocybin retreat.Frontiers in psychiatry 2025 · CEBM Level 4
- Validation of the Imperial Psychedelic Predictor Scale - CORRIGENDUM.Psychological medicine 2025 · CEBM Level 3
- Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin.Molecular psychiatry 2025 · CEBM Level 5
- Psychedelic Therapy, Positive Emotional Experiences, and the Central Role of Self-Compassion.Research square 2025 · CEBM Level 2
- Correction: Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin.Molecular psychiatry 2025 · CEBM Level 5
- N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025 · CEBM Level 4
- Exploring the potential psychological predictors associated with changes in depression, anxiety, and well-being following naturalistic psychedelic use.Journal of psychiatric research 2025 · CEBM Level 3
- Toward a unified taxonomy of information dynamics via Integrated Information Decomposition.Proceedings of the National Academy of Sciences of the United States of America 2025 · CEBM Level 5
- Eigenmodes of the deep unconscious: the neuropsychology of Jungian archetypes and psychedelic experience.Neuroscience of consciousness 2025 · CEBM Level 5
- Null models for comparing information decomposition across complex systems.PLoS computational biology 2025 · CEBM Level 5
- Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2025 · CEBM Level 1
- Correction: Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.Translational psychiatry 2025 · CEBM Level 1
- Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions.Research square 2025 · CEBM Level 5
- Negative affective bias in depression following treatment with psilocybin or escitalopram - a secondary analysis from a randomized trial.Translational psychiatry 2025 · CEBM Level 2
- "Awe-scillations": EEG spectral and complexity representations of awe.bioRxiv : the preprint server for biology 2025 · CEBM Level 4
- Personality change in a trial of psilocybin therapy v. escitalopram treatment for depression.Psychological medicine 2024 · CEBM Level 2
- Personality Change in a Trial of Psilocybin Therapy vs Escitalopram Treatment for Depression - CORRIGENDUM.Psychological medicine 2024 · CEBM Level 5
- A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex.Brain : a journal of neurology 2024 · CEBM Level 5
- Psychological and physiological effects of extended DMT.Journal of psychopharmacology (Oxford, England) 2024 · CEBM Level 2
- Effects of External Stimulation on Psychedelic State Neurodynamics.ACS chemical neuroscience 2024 · CEBM Level 2
- Assessing expectancy and suggestibility in a trial of escitalopram v. psilocybin for depression.Psychological medicine 2024 · CEBM Level 2
- Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study.Journal of psychopharmacology (Oxford, England) 2024 · CEBM Level 3
- Development of the Japanese version of the Ego-Dissolution Inventory (EDI).Neuropsychopharmacology reports 2024 · CEBM Level 4
- Effects of DMT on mental health outcomes in healthy volunteers.Scientific reports 2024 · CEBM Level 3
- Psychedelics and sexual functioning: a mixed-methods study.Scientific reports 2024 · CEBM Level 3
- Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity.Journal of affective disorders 2024 · CEBM Level 4
- The Relationship Between Changes in Mindfulness and Subsequent Changes in Well-Being Following Psychedelic Use: Prospective Cohort Study.JMIR formative research 2024 · CEBM Level 3
- Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self.bioRxiv : the preprint server for biology 2024 · CEBM Level 5
- Psychiatric risks for worsened mental health after psychedelic use.Journal of psychopharmacology (Oxford, England) 2024 · CEBM Level 3
- Improvements in well-being following naturalistic psychedelic use and underlying mechanisms of change in older adults: A prospective cohort study.Research square 2024 · CEBM Level 3
- Brain dynamics predictive of response to psilocybin for treatment-resistant depression.Brain communications 2024 · CEBM Level 4
- Effects of discontinuation of serotonergic antidepressants prior to psilocybin therapy versus escitalopram for major depression.Journal of psychopharmacology (Oxford, England) 2024 · CEBM Level 3
- Psychedelics and the 'inner healer': Myth or mechanism?Journal of psychopharmacology (Oxford, England) 2024 · CEBM Level 2
- Long-term benefits to psychological health and well-being after ceremonial use of Ayahuasca in Middle Eastern and North African immigrants and refugees.Frontiers in psychiatry 2024 · CEBM Level 4
- The flattening of spacetime hierarchy of the N,N -dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework.National science review 2024 · CEBM Level 5
- Effects of Psychedelics in Older Adults: A Prospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 · CEBM Level 3
- Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT.bioRxiv : the preprint server for biology 2024 · CEBM Level 5
- Psychotomimetic compensation versus sensitization.Pharmacology research & perspectives 2024 · CEBM Level 5
- Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?Frontiers in human neuroscience 2024 · CEBM Level 5
- Study protocol for "Psilocybin in patients with fibromyalgia: brain biomarkers of action".Frontiers in psychiatry 2024 · CEBM Level 5
- Interrupting the Psychedelic Experience Through Contextual Manipulation to Study Experience Efficacy.JAMA network open 2024 · CEBM Level 3
- Longitudinal experiences of Canadians receiving compassionate access to psilocybin-assisted psychotherapy.Scientific reports 2024 · CEBM Level 4
- Psilocybin desynchronizes the human brain.Nature 2024 · CEBM Level 4
- A synergistic workspace for human consciousness revealed by Integrated Information Decomposition.eLife 2024 · CEBM Level 5
- Within-subject comparison of near-death and psychedelic experiences: acute and enduring effects.Neuroscience of consciousness 2024 · CEBM Level 4
- Can Psychedelic Use Benefit Meditation Practice? Examining Individual, Psychedelic, and Meditation-Related Factors.medRxiv : the preprint server for health sciences 2024 · CEBM Level 4
- Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being.Journal of psychopharmacology (Oxford, England) 2024 · CEBM Level 2
- Validation of the imperial psychedelic predictor scale.Psychological medicine 2024 · CEBM Level 3
- Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action.Current psychiatry reports 2024 · CEBM Level 5
- Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.Translational psychiatry 2024 · CEBM Level 1
- Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial.EClinicalMedicine 2024 · CEBM Level 2
- Psychological effects of psychedelics in adolescents.Frontiers in child and adolescent psychiatry 2024 · CEBM Level 3
- How does psilocybin therapy work? An exploration of experiential avoidance as a putative mechanism of change.Journal of affective disorders 2023 · CEBM Level 2
- Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience.bioRxiv : the preprint server for biology 2023 · CEBM Level 2
- In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape.Science advances 2023 · CEBM Level 4
- A Bayesian Reanalysis of a Trial of Psilocybin versus Escitalopram for Depression.Psychedelic medicine (New Rochelle, N.Y.) 2023 · CEBM Level 2
- Pattern breaking: a complex systems approach to psychedelic medicine.Neuroscience of consciousness 2023 · CEBM Level 5
- The difference between 'placebo group' and 'placebo control': a case study in psychedelic microdosing.Scientific reports 2023 · CEBM Level 5
- Assessing the risk of symptom worsening in psilocybin-assisted therapy for depression: A systematic review and individual participant data meta-analysis.Psychiatry research 2023 · CEBM Level 1
- Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences.Scientific reports 2023 · CEBM Level 3
- Optimized infusion rates for N,N-dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework.CPT: pharmacometrics & systems pharmacology 2023 · CEBM Level 5
- Case analysis of long-term negative psychological responses to psychedelics.Scientific reports 2023 · CEBM Level 4
- LSD-induced changes in the functional connectivity of distinct thalamic nuclei.NeuroImage 2023 · CEBM Level 2