Sandra Bargeron

Sandra Bargeron is a physician assistant and anesthetist. Her work focuses on surgical preparation and the neurological impacts of anesthesia on the brain. She also addresses how factors such as metabolic health, frailty, and muscle mass affect recovery from surgery.

23 claims checked on air: 3 context 3 overstated 11 supported 6 unverified

What they said on air - context

0:38:03needs contextmoderateHow to Prepare Your Brain for Surgery: What No One Tells You

A 1999 Yale study published in the New England Journal of Medicine demonstrated that a multidisciplinary postoperative intervention in at-risk patients aged 65 and older reduced delirium by 40%.

"the New England Journal of Medicine in 1999 published that study that we were talking about earlier. It was done by Yale and it basically took a population that was at risk, 65 and older, and it looked at them and said, "Okay, we're going to take a multidisciplinary approach following surgery... They dropped delirium 40%." (said at 0:38:03)

The landmark 1999 Yale study published in the New England Journal of Medicine (Inouye et al., PMID 10053175) evaluated a multicomponent nonpharmacological intervention (the Hospital Elder Life Program) and demonstrated a 40% reduction in the odds of developing delirium (matched odds ratio 0.60; 9.9% vs. 15.0%). However, the study was conducted among patients aged 70 and older admitted to general internal medicine units, not postoperative surgical patients.

partial: A multicomponent intervention to prevent delirium in hospitalized older patients. (The New England journal of medicine 1999) · cited 2935x in the literature
"We studied 852 patients 70 years of age or older who had been admitted to the general-medicine service at a teaching hospital... Delirium developed in 9.9 percent of the intervention group as compared with 15.0 percent of the usual-care group, (matched odds ratio, 0.60; 95 percent confidence interval, 0.39 to 0.92)." (abstract, results)
pubmed full study (doi)

0:49:40needs contexthighHow to Prepare Your Brain for Surgery: What No One Tells You

Post-operative cognitive dysfunction (POCD) is a recognized clinical concept by both the American Society of Anesthesiologists and the American Psychological Association.

"introducing a concept called post-operative cognitive dysfunction, which is recognized by the American Society of Anesthesiologists and the APA, and we know this is a reality." (said at 0:49:40)

Postoperative cognitive impairment is an established clinical entity recognized by major professional bodies, but the claim requires context regarding terminology and organization names. The American Society of Anesthesiologists (ASA) launched the Perioperative Brain Health Initiative specifically to address postoperative brain health and cognitive impairment. However, in 2018 an international multispecialty consensus working group recommended updating the nomenclature from "postoperative cognitive dysfunction" (POCD) to the overarching term "perioperative neurocognitive disorders" (PND) to align with the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria established by the American Psychiatric Association (often confused with the American Psychological Association).

context: Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and S… (Anesthesia and analgesia 2018) · cited 96x in the literature
"Two major classification guidelines [Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5) and National Institute for Aging and the Alzheimer Association (NIA-AA)] are used outside of anaesthesia and surgery, and may be useful for inclusion of biomarkers in research. For clinical purposes, it is recommended to use the DSM-5 nomenclature. The working group recommends that 'perioperative neurocognitive disorders' be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period." (abstract, results, passage verified)
pubmed full study (doi)
supports: Improving perioperative brain health: an expert consensus review of key actions for the pe… (British journal of anaesthesia 2021) · cited 197x in the literature
"As part of the American Society of Anesthesiologists (ASA) Perioperative Brain Health Initiative, an international group of experts was invited to review published best practice statements and guidelines." (abstract, background, passage verified)
pubmed full study (doi)

0:59:45needs contextmoderateHow to Prepare Your Brain for Surgery: What No One Tells You

During perimenopause, progesterone is the first hormone to decline.

"On top of that, the first hormone of decline is progesterone." (said at 0:59:45)

Among the primary ovarian steroid hormones (estrogen and progesterone), progesterone is indeed the first to decline during perimenopause. As ovarian reserve diminishes, women experience an increased frequency of inadequate luteal phase function, shortened luteal phases, and anovulatory cycles, leading to early reductions in luteal progesterone production, whereas estradiol levels typically remain preserved or fluctuate erratically until the late perimenopausal transition. However, among all ovarian hormones, peptide hormones such as anti-Müllerian hormone (AMH) and inhibin B decline earlier than progesterone.

context: The endocrinology of the menopause. (The Journal of steroid biochemistry and molecular biology 1999) · cited 106x in the literature
"Early in the menopause transition, when cycle irregularity is first observed, the initial event is a decline in circulating inhibin B levels in the early follicular phase. In the late perimenopause, levels of estradiol and inhibin A also fall, inhibin B levels remain low and FSH is markedly elevated." (abstract, results, passage verified)
pubmed full study (doi)
supports: A longitudinal study of the perimenopausal transition: altered profiles of steroid and pit… (Maturitas 2008) · cited 351x in the literature
"During the premenopausal period an increasing frequency of inadequate luteal function or anovulation occurred and, in the postmenopausal years, the serum levels of progesterone (P) were invariably low. Gradually, the ratio between estrone (E1) and 17-beta-estradiol (E2) increased, reflecting the declining follicular steroidogenesis. A marked decrease in estrogen levels occurred during the 6 month period around the menopause, most pronounced in E2." (abstract, results, passage verified)
pubmed full study (doi)
supports: The endocrinology of perimenopause: need for a paradigm shift. (Frontiers in bioscience (Scholar edition) 2011) · cited 60x in the literature
"Perimenopause, rather than a time of declining estrogen, is characterized by three major hormonal changes that may begin in regularly menstruating women in their mid-thirties: erratically higher estradiol levels, decreased progesterone levels (in normally ovulatory, short luteal phase or anovulatory cycles), and disturbed ovarian-pituitary-hypothalamic feedback relationships." (abstract, results, passage verified)
pubmed full study (doi)

Fact-checked episodes

How to Prepare Your Brain for Surgery: What No One Tells You | Sandra BargeronDr. Tyna Moore · as guest

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