Biosplice's osteoarthritis treatment is a single injection that regrows all tendons in 11 months to the state of 16-year-old tendons.
"And so the one they're getting approval for first is for osteoarthritis. It's a single injection, and in 11 months you regrow all your tendons, but based on the boot disk as what's just described, they're like 16-year-old tendons, even if you're 40, 50, 60, or 70 years old." (said at 0:10:17)
Biosplice Therapeutics developed lorecivivint (SM04690), an intra-articular CLK/DYRK and Wnt pathway inhibitor, as an investigational disease-modifying drug targeting cartilage and inflammation in knee osteoarthritis—not tendon regeneration. In Phase 3 randomized controlled trials (such as OA-10 and OA-11) and systematic meta-analyses, a single injection of lorecivivint failed to meet primary endpoints for pain reduction and did not demonstrate significant structural regeneration or joint space improvement compared to placebo. There is no clinical evidence that lorecivivint regrows tendons or restores joint tissues to an adolescent state.
- contradicts: A Phase 3, 56-week, randomised, double-blind, placebo-controlled study (OA-11) utilising p… (Clinical and experimental rheumatology 2025)
"No discernable treatment effects of LOR compared with PBO were revealed by the analysis of other endpoints. Neither treatment group showed meaningful medial JSW loss over 52 weeks." (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: A Phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10… (Clinical and experimental rheumatology 2025)
"In the full analysis set (FAS), LOR failed to meet the primary endpoint when compared to PBO. No significant treatment differences were noted in other efficacy endpoints." (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: Efficacy and safety of lorecivivint for the treatment of knee osteoarthritis: A systematic… (Journal of orthopaedic surgery (Hong Kong) 2026)
"However, it did not significantly improve functional outcomes, Pain Numeric Rating Scale scores, patient global assessment, or structural changes at the assessed time points." (abstract, results, passage verified)
pubmedfull study (doi)