DavidPerlmutterMD · 2018-05-26 · David Perlmutter (host), Rangan Chatterjee
How to Make Disease Disappear- with Dr. Rangan Chatterjee | The Empowering Neurologist EP. 73
17 research-tied claims examined: 2 contradicted 1 overstated 3 context 10 supported 1 unverified
2 Contradicted by research
LPS in the human body originates exclusively from the gut.
"And it can come from nowhere else; it comes from the gut exclusively." (said at 0:33:34)
The host claimed that lipopolysaccharide (LPS / endotoxin) in the human body originates exclusively from the gut. This claim is contradicted by extensive biomedical evidence establishing that systemic and circulating LPS also originates from non-gut sites harboring Gram-negative bacteria, most prominently the oral cavity (e.g., periodontal infections/pockets) as well as respiratory and urinary tract infections. Studies measuring subgingival and serum LPS activity demonstrate that oral dysbiosis and periodontitis directly contribute to circulating serum LPS levels independently of the gastrointestinal tract.
A study of 10,000 individuals who felt unconnected demonstrated that their risk of illness was triple the risk associated with smoking.
"That study that you just were alluding to of the 10,000 individuals who felt unconnected demonstrated that the risk of illness was in fact triple the risk of smoking." (said at 0:41:28)
No study of 10,000 individuals demonstrating that feeling unconnected carries triple the risk of smoking was located. Landmark meta-analyses evaluating social connection, morbidity, and mortality (such as Holt-Lunstad et al., 2010) benchmark the health risks of social isolation and low social connection as roughly comparable in magnitude to well-established risk factors like smoking (often popularized as equivalent to smoking up to 15 cigarettes a day), rather than threefold higher.
- contradicts: Social relationships and mortality risk: a meta-analytic review. (PLoS medicine 2010) · cited 7313x in the literature
"Across 148 studies (308,849 participants), the random effects weighted average effect size was OR = 1.50 (95% CI 1.42 to 1.59), indicating a 50% increased likelihood of survival for participants with stronger social relationships... The influence of social relationships on risk for mortality is comparable with well-established risk factors for mortality." (abstract, conclusions, passage verified)
pubmedfull study (doi) - contradicts: Benchmarking Social Isolation, Loneliness, and Smoking: Challenges and Opportunities for P… (American journal of epidemiology 2023) · cited 28x in the literature
"Over the past decade, the health implications of social isolation and loneliness garnered global attention due in part to a widely cited meta-analysis that benchmarked associations between cigarette smoking and mortality with associations between several social-relationship measures and mortality. Leaders in health systems, research, government, and popular media have since claimed that the harms of social isolation and loneliness are comparable to that of cigarette smoking." (abstract, passage verified)
pubmedfull study (doi)
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.